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Product Details
PA5-56394
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PDXK. Recombinant protein control fragment (Product #RP-95174).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2645358
Product Specific Information
Immunogen sequence: PNNLKVACEK TVSTLHHVLQ RTIQCAKAQA GEGVRPSPMQ LELRMVQSKR DIEDPEIVVQ ATVL
Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 83%.
Target Information
Pyridoxal kinase (PDXK) converts vitamin B6 to pyridoxal-5-phosphate (PLP), an essential cofactor in the intermediate metabolism of amino acids and neurotransmitters. The PDXK gene encodes a 312-amino acid polypeptide, and expression of the cDNA reveals pyridoxal kinase activity. Northern blot analysis revealed that a major 1.5-kb PDXK transcript is expressed in all tissues tested. The expression of PDXK shows circadian oscillations. The expression of Pdxk in mouse liver and brain is regulated by the 3 PAR bZIP transcription factors, Dbp, Hlf, and Tef, which also show circadian oscillations in expression. Mice devoid of all 3 transcription factors show decreased levels of brain PLP, serotonin, and dopamine, and are highly susceptible to frequently lethal generalized spontaneous and audiogenic epilepsies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epididymis secretory sperm binding protein Li 1a; Pyridoxal kinase; pyridoxamine kinase; Pyridoxine kinase; vitamin B6 kinase
Gene Aliases: 2310036D04Rik; AA119688; C21orf124; C21orf97; C77999; HEL-S-1a; PDXK; PKH; PNK; PRED79
UniProt ID: (Human) O00764, (Mouse) Q8K183
Entrez Gene ID: (Human) 8566, (Mouse) 216134
magnesium ion binding
ATP binding
zinc ion binding
pyridoxal kinase activity
pyridoxal phosphate binding
potassium ion binding
sodium ion binding
lithium ion binding
protein homodimerization activity
nucleotide binding
drug binding
kinase activity
transferase activity
metal ion binding
pyridoxal binding
kinase
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