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            • Primary Antibodies ›
            • CD83 Antibodies

            Proteintech

            CD83 Monoclonal Antibody (HB15e), PE

            View all (61) CD83 antibodies
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            Catalog # PE-65171100TEST
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            Price (USD)
            355.00
            100 Tests
             
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            Cite CD83 Monoclonal Antibody (HB15e), PE

            • Antibody Testing Data (1)
            Application
            CD83 Antibody in Flow Cytometry (Flow)
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            CD83 Antibody (PE-65171100TEST) in Flow

            1X10^6 Human monocytes-derived dendritic cells (induced with GM-CSF+IL-4+TNF-α) were surface stained with 10 µL PE Anti-Human CD83 (Product # PE-65171100TEST), Clone:HB15e) (red) or PE Mouse IgG1 isotype control (black). Cells were not fixed.
            View Product

            CD83 Antibody in Flow Cytometry (Flow)

            Product Details

            PE-65171100TEST

            Applications
            Tested Dilution
            Publications

            Flow Cytometry (Flow)

            10 µL/1x10^6 cells in a 100 µL suspension
            -
            Product Specifications

            Species Reactivity

            Human, Non-human primate

            Host/Isotype

            Mouse / IgG1, kappa

            Class

            Monoclonal

            Type

            Antibody

            Clone

            HB15e

            Conjugate

            PE
            • Unconjugated
            • APC 
            • FITC
            • Request custom conjugation

            Excitation/Emission Max

            565/576 nm View spectra spectra

            Form

            Liquid

            Concentration

            10 µL/Test

            Purification

            Size-exclusion chromatography

            Storage buffer

            PBS, pH 7.2

            Contains

            0.1% sodium azide

            Storage conditions

            4°C, store in dark

            Shipping conditions

            Wet ice

            Target Information

            CD83 cell surface antigen is a 40-45kD glycoprotein expressed by peripheral blood dendritic cells. Peripheral lymphocytes can be induced to express very low levels of CD83 after culture in agents such as Con A or PHA. In immunohistology, CD83 is shown to be expressed strongly by interfollicular interdigitating reticulum cells and more weakly by cells within germinal centres. CD83 is also expressed by Langerhan's cells in the skin. The CD83 antigen is a 186-amino-acid single-chain glycoprotein and this molecule is a member of the immunoglobulin superfamily that is composed of an extracellular V-type Ig-like single domain, a transmembrane region, and a short, 40-amino-acid cytoplasmic tail. CD83 antigen undergoes extensive post-translational glycosylation, since the determined Mr is twice the predicted size of the core protein. However, CD83+ cells have a unique cell surface immuno-phenotype that does not correlate with that of T cells, B cells, NK cells, or cells of the myelomonocytic lineage. CD83+ cells coexpress the highest levels of MHC class II molecules, when compared with other leucocyte lineages. They also co-express T cell markers (CD2, CD5), B cell markers (CD40, CD78), myeloid cell markers (CD13, CD33, CD36), cytokine receptors as well as other cell surface molecules. Diseases associated with CD83 dysfunction include plague and Rift Valley Fever.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

            How to build a flow cytometry experiment with Invitrogen Flow Cytometry Panel Builder
            The Invitrogen Flow Cytometry Panel Builder webtool helps you chose antibody clones, fluorophores, fluorescent proteins, and reagents to design your experiment.
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            Cite this product

            Bioinformatics

            Protein Aliases: B-cell activation protein; CD antigen CD83; CD83; CD83 antigen; CD83 antigen (activated B lymphocytes, immunoglobulin superfamily); Cell surface protein HB15; cell-surface glycoprotein; hCD83

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            Gene Aliases: BL11; CD83; HB15

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            UniProt ID: (Human) Q01151

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            Entrez Gene ID: (Human) 9308

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            Process(es)

            regulation of cytokine production defense response humoral immune response signal transduction response to organic cyclic compound negative regulation of interleukin-4 production positive regulation of interleukin-10 production positive regulation of interleukin-2 production positive regulation of CD4-positive, alpha-beta T cell differentiation
            It has to be done as per old AB suggested Products section.
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