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Invitrogen
PERP Polyclonal Antibody
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Application
FIGURE: 1 / 3
PERP Antibody (PA5-115738) in ICC/IF
Immunocytochemistry analysis of PERP in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115738). Secondary staining was applied with mouse anti-beta tubulin (1 hr at 37°, AlexaFluor 594 conjugated goat anti-rabbit IgG (Red), AlexaFluor 488 conjugated goat anti-mouse IgG (Green) and DAPI.
Product Details
PA5-115738
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PERP(Accession Q96FX8), corresponding to amino acid residues Q37-I87.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2900373
Product Specific Information
Antibody detects endogenous levels of total PERP.
Target Information
The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2, MTBP and PERP, were identified and their genes were cloned recently. PERP, also termed PIGPC1 and THW, is a plasma membrane protein. p53 binds to the promoter of PERP and transcriptionally activates PERP gene then the translated PERP protein mediates the p53 induced apoptosis. The expression of PERP causes cell death. PERP is a mediator of p53 induced apoptosis. PERP has sequence similarity to PMP-22/gas3 and is a new member of the PMP-22/gas3 family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 1110017A08Rik; HGNC:17637; KCP-1; keratinocyte associated protein 1; Keratinocyte-associated protein 1; keratinocytes associated protein 1; p53 apoptosis effector related to PMP-22; p53 apoptosis effector related to PMP22; p53 apoptosis-associated target; P53-induced protein PIGPC1; RP3-496H19.1; Transmembrane protein THW
Gene Aliases: 1110017A08Rik; dJ496H19.1; KCP1; KRTCAP1; PERP; PIGPC1; THW
UniProt ID: (Human) Q96FX8, (Mouse) Q9JK95
Entrez Gene ID: (Human) 64065, (Mouse) 64058
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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