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Product Details
H00005218-B01P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PFTK1 (NP_036527.1, 1 a.a. approximately 451 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MHGYFGCNAA AEPGYSAFVG TPQICVTKMS TRNCQGMDSV IKPLDTIPED KKVRVQRTQS TFDPFEKPAN QVKRVHSENN ACINFKTSST GKESPKVRRH SSPSSPTSPK FGKADSYEKL EKLGEGSYAT VYKGKSKVNG KLVALKVIRL QEEEGTPFTA IREASLLKGL KHANIVLLHD IIHTKETLTL VFEYVHTDLC QYMDKHPGGL HPDNVKLFLF QLLRGLSYIH QRYILHRDLK PQNLLISDTG ELKLADFGLA RAKSVPSHTY SNEVVTLWYR PPDVLLGSTE YSTCLDMWGV GCIFVEMIQG VAAFPGMKDI QDQLERIFLV LGTPNEDTWP GVHSLPHFKP ERFTLYSSKN LRQAWNKLSY VNHAEDLASK LLQCSPKNRL SAQAALSHEY FSDLPPRLWE LTDMSSIFTV PNVRLQPEAG ESMRAFGKNN SYGKSLSNSK H
Target Information
CDK14 (PFTK1)/cyclin Y is a member of the CDC2-related protein kinase family which is expressed primarily in the postnatal and adult nervous system. CDK14 is expressed at high levels in brain, pancreas, kidney, heart, testis, and ovary. CDK14 amino acid residue ser119 is required for its interaction with all four 14-3-3 isoforms, while ser120 may contribute slightly to CDK14 binding. CDK14 acts as a cyclin-dependent kinase that regulates cell cycle progression and cell proliferation. Overexpression of CDK14 predicts resistance to chemotherapy in patients with esophageal squamous cell carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cell division protein kinase 14; Cyclin-dependent kinase 14; hPFTAIRE1; PFTAIRE protein kinase 1; Serine/threonine-protein kinase PFTAIRE-1
Gene Aliases: CDK14; KIAA0834; PFTAIRE1; PFTK1
UniProt ID: (Human) O94921
Entrez Gene ID: (Human) 5218
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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