Product References
SerpinA3K Deficiency Reduces Oxidative Stress in Acute Kidney Injury.
International journal of molecular sciences
González-Soria I,Soto-Valadez AD,Martínez-Rojas MA,Ortega-Trejo JA,Pérez-Villalva R,Gamba G,Sánchez-Navarro A,Bobadilla NA
PA5-38021 was used in Western Blotting to suggest that SerpinA3K is involved in the renal oxidant response, HIF1α/VEGF pathway, and cell apoptosis.
Tue Apr 25 00:00:00 UTC 2023
Pathological mitophagy disrupts mitochondrial homeostasis in Leber's hereditary optic neuropathy.
Cell reports
Danese A,Patergnani S,Maresca A,Peron C,Raimondi A,Caporali L,Marchi S,La Morgia C,Del Dotto V,Zanna C,Iannielli A,Segnali A,Di Meo I,Cavaliere A,Lebiedzinska-Arciszewska M,Wieckowski MR,Martinuzzi A,Moraes-Filho MN,Salomao SR,Berezovsky A,Belfort R,Buser C,Ross-Cisneros FN,Sadun AA,Tacchetti C,Broccoli V,Giorgi C,Tiranti V,Carelli V,Pinton P
PA5-38021 was used in Western Blotting to show that a sustained pathological autophagy and compartment-specific mitophagy activity affects Leber's hereditary optic neuropathy patient-derived cells and cybrids, as well as induced pluripotent-stem-cell-derived neurons.
Tue Jul 19 00:00:00 UTC 2022
Anmyungambi Decoction Ameliorates Obesity through Activation of Non-Shivering Thermogenesis in Brown and White Adipose Tissues.
Antioxidants (Basel, Switzerland)
Park WY,Song G,Boo M,Kim HI,Park JY,Jung SJ,Choi M,Kim B,Kim YD,Kim MH,Kim KI,Kwak HJ,Leem J,Um JY,Park J
PA5-38021 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to support the clinical use of AMGB decoction for obesity treatment by studying its mechanisms. AMGB decoction alleviates obesity through the activation of the lipolysis-thermogenesis program and the elimination of pathological ROS in thermogenic adipose tissues.
Mon Dec 26 00:00:00 UTC 2022
Lactobacillus plantarum HY7715 Ameliorates Sarcopenia by Improving Skeletal Muscle Mass and Function in Aged Balb/c Mice.
International journal of molecular sciences
Lee K,Kim J,Park SD,Shim JJ,Lee JL
PA5-38021 was used in Western Blotting to study whether probiotics can improve muscle mass, muscle strength and affect physical performance.
Thu Sep 16 00:00:00 UTC 2021
Lactobacillus plantarum HY7715 Ameliorates Sarcopenia by Improving Skeletal Muscle Mass and Function in Aged Balb/c Mice.
International journal of molecular sciences
Lee K,Kim J,Park SD,Shim JJ,Lee JL
PA5-38021 was used in Western Blotting to study whether probiotics can improve muscle mass, muscle strength and affect physical performance.
Thu Sep 16 00:00:00 UTC 2021
Random errors in protein synthesis activate an age-dependent program of muscle atrophy in mice.
Communications biology
Moore J,Akbergenov R,Nigri M,Isnard-Petit P,Grimm A,Seebeck P,Restelli L,Frank S,Eckert A,Thiam K,Wolfer DP,Shcherbakov D,Böttger EC
PA5-38021 was used in Western Blot to investigate the effects of the ribosomal ambiguity (ram) mutation Rps2-A226Y on age-related pathologies in mice.
Tue Jun 08 00:00:00 UTC 2021
Random errors in protein synthesis activate an age-dependent program of muscle atrophy in mice.
Communications biology
Moore J,Akbergenov R,Nigri M,Isnard-Petit P,Grimm A,Seebeck P,Restelli L,Frank S,Eckert A,Thiam K,Wolfer DP,Shcherbakov D,Böttger EC
PA5-38021 was used in Western Blot to investigate the effects of the ribosomal ambiguity (ram) mutation Rps2-A226Y on age-related pathologies in mice.
Tue Jun 08 00:00:00 UTC 2021
Post-Treatment with Amorfrutin B Evokes PPARγ-Mediated Neuroprotection against Hypoxia and Ischemia.
Biomedicines
Wnuk A,Przepiórska K,Pietrzak BA,Kajta M
PA5-38021 was used in Western Blotting to demonstrate for the first time that amorfrutin B, a selective modulator of peroxisome proliferator-activated receptor gamma-PPARγ, can protect brain neurons from hypoxia- and ischemia-induced degeneration when applied at 6 h post-treatment in primary cultures.
Wed Jul 21 00:00:00 UTC 2021
Post-Treatment with Amorfrutin B Evokes PPARγ-Mediated Neuroprotection against Hypoxia and Ischemia.
Biomedicines
Wnuk A,Przepiórska K,Pietrzak BA,Kajta M
PA5-38021 was used in Western Blotting to demonstrate for the first time that amorfrutin B, a selective modulator of peroxisome proliferator-activated receptor gamma-PPARγ, can protect brain neurons from hypoxia- and ischemia-induced degeneration when applied at 6 h post-treatment in primary cultures.
Wed Jul 21 00:00:00 UTC 2021
Hsp22 Deficiency Induces Age-Dependent Cardiac Dilation and Dysfunction by Impairing Autophagy, Metabolism, and Oxidative Response.
Antioxidants (Basel, Switzerland)
Wu W,Sun X,Shi X,Lai L,Wang C,Xie M,Qin G,Qiu H
PA5-38021 was used in Western Blot to show that Hsp22 played an essential role in the non-stressed heart during the early stage of aging, which may bring new insight into understanding the pathogenesis of age-related dilated cardiomyopathy.
Wed Sep 29 00:00:00 UTC 2021
Transcriptional and Histochemical Signatures of Bone Marrow Mononuclear Cell-Mediated Resolution of Synovitis.
Frontiers in immunology
Menarim BC,El-Sheikh Ali H,Loux SC,Scoggin KE,Kalbfleisch TS,MacLeod JN,Dahlgren LA
PA5-38021 was used in Immunohistochemistry (Paraffin) to study differential transcriptional signatures of bone marrow mononuclear cells in response to normal and inflamed synovial fluid.
Thu Feb 10 00:00:00 UTC 2022
Role of IRE1α in podocyte proteostasis and mitochondrial health.
Cell death discovery
Navarro-Betancourt JR,Papillon J,Guillemette J,Iwawaki T,Chung CF,Cybulsky AV
PA5-38021 was used in Western Blotting to characterize the mechanism by which IRE1α mediates podocyte proteostasis in adriamycin nephrosis and demonstrate a novel role of IRE1α in maintaining mitochondrial health.
Thu Nov 19 00:00:00 UTC 2020
Overexpression of apoptosis inducing factor aggravates hypoxic-ischemic brain injury in neonatal mice.
Cell death & disease
Li T,Li K,Zhang S,Wang Y,Xu Y,Cronin SJF,Sun Y,Zhang Y,Xie C,Rodriguez J,Zhou K,Hagberg H,Mallard C,Wang X,Penninger JM,Kroemer G,Blomgren K,Zhu C
PA5-38021 was used in Western Blot to study AIF and its casual role in neonatal HI brain injury.
Thu Jan 30 00:00:00 UTC 2020
Glucose-Induced Expression of DAPIT in Pancreatic β-Cells.
Biomolecules
Leguina-Ruzzi A,Vodičková A,Holendová B,Pavluch V,Tauber J,Engstová H,Dlasková A,Ježek P
PA5-38021 was used in Western Blotting to demonstrate that when a fraction predominates of vestigial ATP synthase molecules deficient of USMG5/DAPIT, rat pancreatic β-cells (INS-1E cells) almost do not elevate ATP levels as responding to high glucose.
Fri Jul 10 00:00:00 UTC 2020
Myricetin improves endurance capacity by inducing muscle fiber type conversion via miR-499.
Nutrition & metabolism
Wu L,Ran L,Lang H,Zhou M,Yu L,Yi L,Zhu J,Liu L,Mi M
PA5-38021 was used in Western Blotting to assess the effects of natural flavonoid myricetin on exercise endurance and muscle fiber constitution, and investigated the underlying mechanism of myricetin in vivo and in vitro.
Tue Sep 28 00:00:00 UTC 2021
Myricetin improves endurance capacity by inducing muscle fiber type conversion via miR-499.
Nutrition & metabolism
Wu L,Ran L,Lang H,Zhou M,Yu L,Yi L,Zhu J,Liu L,Mi M
PA5-38021 was used in Western Blotting to assess the effects of natural flavonoid myricetin on exercise endurance and muscle fiber constitution, and investigated the underlying mechanism of myricetin in vivo and in vitro.
Tue Sep 28 00:00:00 UTC 2021
Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Du K,Ramachandran A,McGill MR,Mansouri A,Asselah T,Farhood A,Woolbright BL,Ding WX,Jaeschke H
Published figure using PGC1 alpha polyclonal antibody (Product # PA5-38021) in Immunofluorescence
Sun Oct 01 00:00:00 UTC 2017
Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Du K,Ramachandran A,McGill MR,Mansouri A,Asselah T,Farhood A,Woolbright BL,Ding WX,Jaeschke H
Published figure using PGC1 alpha polyclonal antibody (Product # PA5-38021) in Immunofluorescence
Sun Oct 01 00:00:00 UTC 2017
Nkx6.1 decline accompanies mitochondrial DNA reduction but subtle nucleoid size decrease in pancreatic islet β-cells of diabetic Goto Kakizaki rats.
Scientific reports
Špaček T,Pavluch V,Alán L,Capková N,Engstová H,Dlasková A,Berková Z,Saudek F,Ježek P
PA5-38021 was used in Western Blotting to report Nkx6.1 mRNA and protein were declining with age and decreasing with fasting hyperglycemia in Goto Kakizaki rats.
Wed Nov 15 00:00:00 UTC 2017
