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            • Primary Antibodies ›
            • PHIP Antibodies

            Bethyl Laboratories

            PHIP Polyclonal Antibody

            View all (9) PHIP antibodies

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            Catalog # A302-055A
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            Cite PHIP Polyclonal Antibody

            • Antibody Testing Data (1)
            Application
            PHIP Antibody in Western Blot (WB)
            Group 53 Created with Sketch.

            FIGURE: 1 / 1

            PHIP Antibody (A302-055A) in WB

            Detection of human PHIP by western blot and immunoprecipitation. Samples: Whole cell lysate (5, 15 and 50 µg for WB; 1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-PHIP antibody (Product # A302-055A) used for WB at 0.04 µg/mL (A) and 1 µg/mL (B) and used for IP at 3 µg/mg lysate. PHIP was also immunoprecipitated by rabbit anti-PHIP antibody A302-054A, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times of 3 minutes seconds (A and B).
            View Product

            PHIP Antibody in Western Blot (WB)

            Product Details

            A302-055A

            Applications
            Tested Dilution
            Publications

            Western Blot (WB)

            1:2,000-1:10,000
            -

            Immunoprecipitation (IP)

            2-5 µg/mg lysate
            -
            Product Specifications

            Species Reactivity

            Human

            Host/Isotype

            Rabbit / IgG

            Class

            Polyclonal

            Type

            Antibody

            Immunogen

            Region between residue 1771 and 1821 of human pleckstrin homology domain interacting protein.
            View immunogen

            Conjugate

            Unconjugated

            Form

            Liquid

            Concentration

            0.20 mg/mL

            Purification

            Antigen affinity chromatography

            Storage buffer

            TBS, pH 7.0 to 8.0, with 0.1% BSA

            Contains

            0.09% sodium azide

            Storage conditions

            4°C

            Shipping conditions

            Ambient (domestic); Wet ice (international)

            Product Specific Information

            The recommended shelf life for this product is 1 year from date of receipt.

            Based on 100% sequence identity, this antibody is predicted to react with Mouse

            Target Information

            PHIP (pleckstrin homology domain interacting protein), also known as ndrp or WDR11, is a 1,821 amino acid protein that contains eight N-terminal WD40 repeats and two bromodomains. It is expressed in skeletal muscle (localizing to the cytosol and nucleus) and primary beta cells (localizing to the nucleus) and acts as a transcriptional activator. PHIP is known to interact with various members of the insulin receptor substrate (IRS) family. The IRS family of proteins mediate insulin receptor signaling and play an important role in insulin-producing beta cell proliferation and survival. PHIP specifically associates with the PH domain of IRS-1 and may function to link IRS-1 to insulin receptors, indicating a vital role of PHIP in the regulation of insulin signaling.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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            Cite this product

            Bioinformatics

            Protein Aliases: DDB1 and CUL4 associated factor 14; DDB1- and CUL4-associated factor 14; FLJ20705; IRS-1 PH domain-binding protein; PH-interacting protein; PHIP; WD repeat-containing protein 11

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            Gene Aliases: BRWD2; DCAF14; ndrp; PHIP; WDR11

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            UniProt ID: (Human) Q8WWQ0

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            Entrez Gene ID: (Human) 55023

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            Function(s)

            insulin receptor binding protein binding lysine-acetylated histone binding

            Process(es)

            regulation of protein phosphorylation cytoskeleton organization positive regulation of cell proliferation insulin receptor signaling pathway regulation of cell shape regulation of cell morphogenesis negative regulation of apoptotic process positive regulation of insulin-like growth factor receptor signaling pathway positive regulation of mitotic nuclear division positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of extrinsic apoptotic signaling pathway
            It has to be done as per old AB suggested Products section.
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