Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
21739-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PI3K p110(beta) Fusion Protein Ag16456 (139-373 aa encoded by BC114432)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.39 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is specific to PIK3CB.
Immunogen sequence: SLKDPEVNE FRRKMRKFSE EKILSLVGLS WMDWLKQTYP PEHEPSIPEN LEDKLYGGKL IVAVHFENCQ DVFSFQVSPN MNPIKVNELA IQKRLTIHGK EDEVSPYDYV LQVSGRVEYV FGDHPLIQFQ YIRNCVMNRA LPHFILVECC KIKKMYEQEM IAIEAAINRN SSNLPLPLPP KKTRIISHVW ENNNPFQIVL VKGNKLNTEE TVKVHVRAGL FHGTELLCKT IVSSEV (139-373 aa encoded by BC114432)
Target Information
PIK3CB (phosphatyidylinositol 4,5-biphosphate 3-kinase catalyic subunit beta isoform) is a phosphoinositide-3-kinase that phosphorylates PtdIns (phosphatidylinositol), PtdIns4P (phosphatidylinositol 4-phosphate), and PtdIns(4,5)P2 (phosphatidylinositol 4,5-biphosphate) to generate phosphatidylinositol 3,4,5-triphosphate (PIP3). PIP3 plays a key role in recruiting PH domain-containing proteins to the membrane and activating signaling cascades involved in cell growth, survival, proliferation, motility, and morphology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; phosphoinositide-3-kinase, catalytic, beta polypeptide; PI3-kinase p110 subunit beta; PI3-kinase subunit beta; PI3K-beta; pi3kcb; PtdIns-3-kinase p110; ptdIns-3-kinase subunit beta; PtdIns-3-kinase subunit p110-beta; Serine/threonine protein kinase PIK3CB
Gene Aliases: P110BETA; PI3K; PI3KBETA; PIK3C1; PIK3CB
UniProt ID: (Human) P42338
Entrez Gene ID: (Human) 5291
activation of MAPK activity
endothelial cell proliferation
regulation of cell-matrix adhesion
phosphatidylinositol biosynthetic process
cellular calcium ion homeostasis
autophagy
chemotaxis
homophilic cell adhesion via plasma membrane adhesion molecules
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
G-protein coupled receptor signaling pathway
positive regulation of autophagy
positive regulation of gene expression
phosphatidylinositol 3-kinase signaling
regulation of phosphatidylinositol 3-kinase signaling
cell migration
platelet activation
phosphatidylinositol-3-phosphate biosynthetic process
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
embryonic cleavage
phosphatidylinositol phosphorylation
vascular endothelial growth factor receptor signaling pathway
phosphatidylinositol-mediated signaling
T cell receptor signaling pathway
leukocyte migration
angiogenesis involved in wound healing
platelet aggregation
regulation of clathrin-mediated endocytosis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support