Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: PDLIQLRKIR DQHLVWLNHK GVRQKRLNVW LGIKNEDADE NYFINEEDEN LPHYDEKTWF VEDINRVQAE DLLYGKPDGA FLIRESSKK
PIK3R3 binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. It is a component of a heterodimer of p110 (catalytic) and p55 (regulatory) subunits. The protein is expressed at highest levels in brain and testis. Lower levels are detected in adipose tissue, kidney, heart, lung and skeletal muscle. The protein contains 2 SH2 domains.
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Protein Aliases: p55PIK; Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; Phosphatidylinositol 3-kinase regulatory subunit gamma; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 3 (p55, gamma); phosphoinositide-3-kinase, regulatory subunit 3 (gamma); PI3-kinase regulatory subunit gamma; PI3-kinase subunit p55-gamma; PI3K regulatory subunit gamma; ptdIns-3-kinase regulatory subunit gamma; ptdIns-3-kinase regulatory subunit p55-gamma; RP4-533D7.2
Gene Aliases: AA414954; p55; p55-GAMMA; p55PIK; PIK3R3
UniProt ID: (Human) Q92569, (Mouse) Q64143
Entrez Gene ID: (Human) 8503, (Mouse) 18710
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