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Product Details
15318-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PI4K2A Fusion Protein Ag7564 (131-479 aa encoded by BC003167)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: YQGSSGSYF VKDPQGRIIA VFKPKNEEPY GHLNPKWTKW LQKLCCPCCF GRDCLVLNQG YLSEAGASLV DQKLELNIVP RTKVVYLASE TFNYSAIDRV KSRGKRLALE KVPKVGQRFN RIGLPPKVGS FQLFVEGYKD ADYWLRRFEA EPLPENTNRQ LLLQFERLVV LDYIIRNTDR GNDNWLIKYD CPMDSSSSRD TDWVVVKEPV IKVAAIDNGL AFPLKHPDSW RAYPFYWAWL PQAKVPFSQE IKDLILPKIS DPNFVKDLEE DLYELFKKDP GFDRGQFHKQ IAVMRGQILN LTQALKDNKS PLHLVQMPPV IVETARSHQR SSSESYTQSF QSRKPFFSWW (131-479 aa encoded by BC003167)
Target Information
PI4K2A (PI4K2 alpha) lipid kinase or phosphatidylinositol 4-kinase type 2 alpha is involved in the formation of phosphatidylinositolpolyphosphates (PtdInsPs) which are centrally involved in many biologic processes ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4K2A phosphorylates PtdIns at the D-4 position which is an essential step in the biosynthesis of PtdInsPs. PI4K2A is a novel regulator of tumor growth by its action on angiogenesis and HIF-1alpha regulation. PI4K2A generates PtdIns4P-rich domains within the Golgi which regulate targeting of clathrin adaptor AP-1 complexes. PI4K2A is also required for Wnt to regulate LRP6 phosphorylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 55 kDa type II phosphatidylinositol 4-kinase; null; phosphatidylinositol 4-kinase; Phosphatidylinositol 4-kinase type 2-alpha; phosphatidylinositol 4-kinase type II; phosphatidylinositol 4-kinase type II (PI4KII); Phosphatidylinositol 4-kinase type II-alpha
Gene Aliases: Pi4k2; PI4K2A; PI4KII; PIK42A
UniProt ID: (Human) Q9BTU6, (Mouse) Q2TBE6, (Rat) Q99M64
Entrez Gene ID: (Human) 55361, (Mouse) 84095, (Rat) 114554
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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