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Product Details
PA5-115758
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PIK3CD(Accession O00329), corresponding to amino acid residues R246-V296.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2900393
Product Specific Information
Antibody detects endogenous levels of total PIK3CD.
Target Information
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: catalytic phosphatidylinositol 3-kinase delta; p100 delta; phosphatidylinositol 3-kinase catalytic delta polypeptide; phosphatidylinositol 3-kinase catalytic subunit delta; phosphatidylinositol 3-kinase p110 delta; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta; phosphoinositide 3 kinase P110delta; phosphoinositide-3-kinase C; phosphoinositide-3-kinase, catalytic, delta polypeptide; phosphoinositide-3-kinase, catalytic, delta polypeptide variant p37delta; PI3-kinase p110 subunit delta; PI3-kinase subunit delta; PI3K delta; PI3K-delta; PI3K-p110delta; pi3kcd; PI3Kdelta; PI3Kp110delta; ptdIns-3-kinase subunit delta; PtdIns-3-kinase subunit p110-delta
Gene Aliases: 2410099E07Rik; 2610208K16Rik; APDS; AW545373; IMD14; p110D; P110DELTA; PI3K; PIK3CD
UniProt ID: (Human) O00329, (Mouse) O35904
Entrez Gene ID: (Human) 5293, (Mouse) 18707, (Rat) 366508
protein binding
ATP binding
1-phosphatidylinositol-3-kinase activity
phosphatidylinositol 3-kinase activity
1-phosphatidylinositol-4-phosphate 3-kinase activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
phosphotransferase activity, alcohol group as acceptor
kinase
natural killer cell differentiation
cytokine production
adaptive immune response
mast cell chemotaxis
respiratory burst involved in defense response
protein phosphorylation
phosphatidylinositol biosynthetic process
inflammatory response
signal transduction
positive regulation of gene expression
T cell chemotaxis
phosphatidylinositol 3-kinase signaling
regulation of phosphatidylinositol 3-kinase signaling
natural killer cell activation
T cell differentiation
positive regulation of cell migration
neutrophil chemotaxis
natural killer cell chemotaxis
B cell chemotaxis
phosphatidylinositol-3-phosphate biosynthetic process
T cell activation
B cell activation
mast cell degranulation
innate immune response
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
T cell receptor signaling pathway
B cell receptor signaling pathway
mast cell differentiation
neutrophil extravasation
B cell homeostasis
immune system process
chemotaxis
cell surface receptor signaling pathway
phosphorylation
cell differentiation
platelet activation
homeostasis of number of cells
defense response to fungus
cell chemotaxis
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