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Product Details
PA5-82895
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TGS1. Recombinant protein control fragment (Product #RP-93799).
Conjugate
Unconjugated
Form
Liquid
Concentration
0.10 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2790051
Product Specific Information
Immunogen sequence: PELAKYWAQR YRLFSRFDDG IKLDREGWFS VTPEKIAEHI AGRVSQSFKC DVVVDAFCGV GGNTIQFALT GMRVIAIDID PVKIALARNN AE
Target Information
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cap-specific guanine-N(2) methyltransferase; cap-specific guanine-N2 methyltransferase; CLL-associated antigen KW-2; Hepatocellular carcinoma-associated antigen 137; nuclear receptor coactivator 6 interacting protein; Nuclear receptor coactivator 6-interacting protein; PIMT; PRIP-interacting protein with methyltransferase motif; Trimethylguanosine synthase
Gene Aliases: HCA137; NCOA6IP; PIMT; PIPMT; TGS1
UniProt ID: (Human) Q96RS0
Entrez Gene ID: (Human) 96764
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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