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Immunogen sequence: TVSYLLEGGS MAHEDFCGHT GKMNPGDLQW MTAGRGILHA EMPCSEEPAH GLQLWVNLRS SEKMVEPQYQ ELKSEEIPKP SKDGVTVAVI SGEALGIKSK VYTRTPTLYL DF
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 97%.
This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Pirin; pirin (iron-binding nuclear protein); pirinin; Probable quercetin 2,3-dioxygenase PIR; Probable quercetinase
Gene Aliases: PIR
UniProt ID: (Human) O00625, (Rat) Q5M827
Entrez Gene ID: (Human) 8544, (Rat) 363465
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