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Application
FIGURE: 1 / 1
PIp1 Antibody (BSM-51197M) in WB
Lane 1: C6; Lane 2: HeLa; Lane 3: mouse cerebellum lysate at 20 µg per lane, probed with bsm-51197M PIp1 (538CT16.5.4) Monoclonal Antibody at 1:1,000 dilution and 4°C overnight incubation, followed by secondary antibody incubation for 60 min at room temperature.
Product Details
BSM-51197M
Product Specifications
Species Reactivity
Mouse,
Rat,
Human
Host/Isotype
Mouse
/ IgM
Class
Monoclonal
Type
Antibody
Clone
4E7
Immunogen
KLH conjugated synthetic peptide between 248-277 amino acids from the central region of rat PIp1.
Conjugate
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Purification
Size-exclusion - Dialysis
Storage buffer
TBS, pH 7.4, with 40% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
PLP1 is a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene.This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Lipophilin; major myelin proteolipid protein; Myelin proteolipid protein; myelin synthesis deficiency; PLP; proteolipid; proteolipid protein (myelin) 1; Proteolipid protein (Pelizaeus-Merzbacher disease spastic paraplegia 2 uncomplicated); Proteolipid protein (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated); rump shaker
Gene Aliases: DM20; GPM6C; HLD1; jimpy; jp; MMPL; msd; PLP; PLP/DM20; PLP1; PMD; rsh; SPG2
UniProt ID: (Human) P60201, (Mouse) P60202, (Rat) P60203
Entrez Gene ID: (Human) 5354, (Mouse) 18823, (Rat) 24943
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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