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PKNOX2 Antibody (PA5-99267) in IHC (P)
Immunohistochemistry analysis of PKNOX2 in mouse testis tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with PKNOX2 polyclonal antibody (Product # PA5-99267) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-99267
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human PKNOX2(Accession Q96KN3), corresponding to amino acid residues H369-Q419.
偶联物
Unconjugated
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2818200
产品详细信息
Antibody detects endogenous levels of total PKNOX2.
靶标信息
PREP-2 (Pbx-regulating protein-2), also known as PBX/knotted 1 homeobox 2 or PKNOX2, is a widely expressed protein belonging to the TALE (three amino acid loop extension)/MEIS family. PREP-2 is a DNA-binding protein that forms stable complexes with Pbx proteins. It is highly homologous to the related protein PREP-1, but displays a more restricted tissue distribution and a higher DNA-dissociation rate. Like PREP-1, PREP-2 forms a heterodimer with Pbx 1. The PREP-2-Pbx 1 dimer is relocated to the nucleus where it associates with HoxB1 to form a ternary complex. In contrast with PREP-1, which acts to increase transcriptional activation in this ternary complex, PREP-2 leads to a slight decrease in transcriptional activity of the ternary complex. Multiple isoforms exist for PREP-2, localizing to the nucleus or cytoplasm. Cytoplasmic isoforms are believed to colocalize with F-actin, G-actin and tubulin/microtubules.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Homeobox protein PKNOX2; Homeobox protein PREP-2; homeodomain containing transcription factor PREP2; PBX/knotted homeobox 2
基因别名: D230005H23Rik; Pknox2; PREP2
UniProt ID: (Mouse) Q8BG99
Entrez Gene ID: (Human) 63876, (Mouse) 208076
