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PLUNC is the human homolog of murine plunc and is specifically expressed in the upper airways and nasopharyngeal regions. The exact biological function of this protein is not known, however, it has been suggested to be involved in inflammatory responses to irritants in the upper airways. It may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The exact biological function of this gene is not known, however, it has been suggested to be involved in inflammatory responses to irritants in the upper airways. It may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only two is known.
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Protein Aliases: BPI fold containing family A, member 1; BPI fold-containing family A member 1; ligand-binding protein RYA3; LPLUNC3; Lung-specific protein X; LUNXNASG; Nasopharyngeal carcinoma-related protein; Palate lung and nasal epithelium clone protein; palate, lung and nasal epithelium associated; protein Plunc; Secretory protein in upper respiratory tracts; short palate; Short PLUNC1; SPLUNC1; SPLUNC1SPURT; tracheal epithelium enriched protein; Tracheal epithelium-enriched protein; Von Ebner protein Hl
Gene Aliases: bA49G10.5; BPIFA1; LUNX; NASG; PLUNC; SPLUNC1; SPURT; UNQ787/PRO1606
UniProt ID: (Human) Q9NP55
Entrez Gene ID: (Human) 51297
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