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POTE8 (Prostate, ovary, testis-expressed protein on chromosome 8), also known as A26A1 (ANKRD26-like family A member 1) or POTEA (POTE ankyrin domain family, member A), is a 498 amino acid protein that contains five ANK repeats and is thought to participate in signaling events during reproductive development. POTE8 exists as two alternatively spliced isoforms which are encoded by a gene that maps to human chromosome 8. Consisting of nearly 146 million base pairs, chromosome 8 encodes over 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that maps to chromosome 8.
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Protein Aliases: ANKRD26-like family A member 1; ANKRD26-like family A, member 1; cancer/testis antigen family 104, member 3; POTE ankyrin domain family member A; POTE ankyrin domain family, member A; POTE-8; Prostate, ovary, testis-expressed protein on chromosome 8; protein expressed in prostate, ovary, testis, and placenta 8
Gene Aliases: A26A1; CT104.3; POTE-8; POTE8; POTEA
UniProt ID: (Human) Q6S8J7
Entrez Gene ID: (Human) 340441
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