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Product Details
BS-5423R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human PPAP2A, amino acids 31-130.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Phosphatidic acid phosphatase type 2 (PAP2) was originally identified as a plasma membrane enzyme that catalyses the dephosphorylation of the putative second messenger, phosphatidic acid (PA) to diacylglycerol (DG). Subsequently, multiple isoforms of PAP2 were cloned [2-5]. It was found that these enzymes dephosphorylate a number of lipid phosphates in vitro other than PA, including the potent bioactive lipids, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Therefore, they have been renamed lipid phosphate phosphatases (LPPs). Currently, there are four members of this family called LPP1, LPP1a, LPP2 and LPP3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 35 kDa PAP; Hic53; hydrogen peroxide inducible protein 53; Hydrogen peroxide-inducible protein 53; Lipid phosphate phosphohydrolase 1; lipid phosphate phosphohydrolase 1a; mPAP; PAP-2a; PAP2-alpha; PAP2a; PAP2alpha2; PAPalpha1; Phosphatidate phosphohydrolase type 2a; Phosphatidic acid phosphatase 2a; phosphatidic acid phosphatase type 2A; phosphatidic acid phosphohydrolase type 2a; Phospholipid phosphatase 1; type-2 phosphatidic acid phosphatase alpha
Gene Aliases: Hic53; Hpic53; LLP1a; LPP-1; LPP1; mPAP; PAP-2a; PAP2; PAP2-alpha; PAP2a; PLPP1; PPAP2A
UniProt ID: (Human) O14494, (Mouse) Q61469
Entrez Gene ID: (Human) 8611, (Mouse) 19012, (Rat) 64369
protein dephosphorylation
lipid metabolic process
phospholipid metabolic process
protein kinase C-activating G-protein coupled receptor signaling pathway
negative regulation of cell proliferation
germ cell migration
regulation of lipid metabolic process
sphingolipid biosynthetic process
intracellular steroid hormone receptor signaling pathway
androgen receptor signaling pathway
phospholipid dephosphorylation
diacylglycerol biosynthetic process
sphingosine metabolic process
ceramide metabolic process
signal transduction
dephosphorylation
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