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The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. This protein is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosynthesis. This gene and PAICS/AIRC, a bifunctional enzyme catalyzing steps six and seven in the purine nucleotide biosynthesis pathway, are located in close proximity on chromosome 4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Amidophosphoribosyltransferase; ATase; EC 2.4.2.14; glutamine phosphoribosylpyrophosphatate amidotransferase; Glutamine phosphoribosylpyrophosphate amidotransferase; glutamine PRPP amidotransferase; GPAT
Gene Aliases: 5730454C12Rik; AA408689; AA675351; AI507113; ATASE; C79945; GPAT; PPAT; PRAT
UniProt ID: (Human) Q06203, (Rat) P35433, (Mouse) Q8CIH9
Entrez Gene ID: (Human) 5471, (Dog) 611407, (Rat) 117544, (Mouse) 231327
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