Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Mouse NAP-2/PPBP/CXCL7.
Members of the a-chemokine subfamily of inducible, secreted, pro-inflammatory cytokines contain a similar motif, in which the first two cysteine residues are separated by a single residue (Cys-X-Cys), and are also chemotactic for neutrophils. The platelet basic protein (PBP), a member of the a-chemokine family, resides in the a-granules of platelets and is released upon their activation. Proteolytic cleavage of the amino terminus of PBP leads to the generation of several peptides, which include mature PBP, connective tissue-activating peptide III (CTAP III, also designated low affinity platelet factor IV (LA-PF4)), b-thromboglobulin (b-TG), and neutrophil-activating peptide 2 (NAP-2). PBP and its N-truncated derivatives mediate inflammation and wound healing. Specifically, NAP-2 activates chemotaxis and degranulation in neutrophils during inflammation. The gene encoding human PBP maps to chromosome 4q12-q13.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: chemokine (C-X-C motif) ligand 7; platelet basic protein
Gene Aliases: 2400003M24Rik; AI854500; b-TG1; beta-TG; CTAP3; CTAPIII; Cxcl7; LA-PF4; LDGF; MDGF; NAP-2; NAP-2-L1; Scyb7; TGB; TGB1; THBGB1
Entrez Gene ID: (Mouse) 57349
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