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Product Details
18801-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.14 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Target Information
Neurabin I is a brain-specific protein which contains an F-actin binding domain, a PDZ domain, a transmembrane-protein-interacting-domain, and a coiled-coil region. As its structure suggests, neurabin I is a promiscuous protein binding to F-actin, protein phosphatase 1, TGN38, and p70 S6 kinase. Found exclusively in brain, this protein is highly concentrated in the synapse and has also been shown to be enriched in the lamellipodia of the growth cone during neuronal development. Neurabin I appears to be a bridging protein by targeting other proteins to the synapse or by linking membrane proteins to the actin cytoskeleton.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: actin-binding protein neurabin; neurabin 1; Neurabin I; Neurabin-1; Neurabin-I; neural tissue-specific F-actin binding protein; Neural tissue-specific F-actin-binding protein I; p180; PP1bp175; Protein phosphatase 1 regulatory subunit 9A; protein phosphatase 1, regulatory (inhibitor) subunit 9A; protein phosphatase 1, regulatory subunit 9A
Gene Aliases: 2810430P21Rik; 4930518N04Rik; 5330407E15; A230094E16Rik; BB181831; KIAA1222; mKIAA1222; Neb1; Neurabin-I; NRB; NRB1; NRBI; PPP1R9A
UniProt ID: (Human) Q9ULJ8, (Rat) O35867
Entrez Gene ID: (Human) 55607, (Mouse) 243725, (Rat) 84685
actin filament organization
positive regulation of neuron projection development
calcium-mediated signaling
neuron projection development
positive regulation of protein kinase activity
negative regulation of synaptic transmission
regulation of filopodium assembly
negative regulation of stress fiber assembly
positive regulation of dendritic spine development
cellular response to toxic substance
negative regulation of long-term synaptic potentiation
positive regulation of long term synaptic depression
aging
regulation of actin filament polymerization
regulation of synapse structural plasticity
regulation of synapse assembly
excitatory postsynaptic potential
regulation of dendritic spine morphogenesis
negative regulation of spontaneous neurotransmitter secretion
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