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Invitrogen
PRDM12 Polyclonal Antibody
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Application
FIGURE: 1 / 1
PRDM12 Antibody (PA5-110215) in WB
Western blot analysis of PRDM12 in extracts of U-87MG cells. Samples were incubated with PRDM12 Polyclonal antibody (Product # PA5-110215) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-110215
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 100-330 of human PRDM12 (NP_067632.2).
Conjugate
Unconjugated
Form
Liquid
Concentration
0.95 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2855626
Product Specific Information
Immunogen sequence: LGIFSKTWIK AGTEMGPFTG RVIAPEHVDI CKNNNLMWEV FNEDGTVRYF IDASQEDHRS WMTYIKCARN EQEQNLEVVQ IGTSIFYKAI EMIPPDQELL VWYGNSHNTF LGIPGVPGLE EDQKKNKHED FHPADSAAGP AGRMRCVICH RGFNSRSNLR SHMRIHTLDK PFVCRFCNRR FSQSSTLRNH VRLHTGERPY KCQVCQSAYS QLAGLRAHQK SARHRPPSTA L
Target Information
This gene encodes a transcriptional regulator of sensory neuronal specification that plays a critical role in pain perception. The encoded protein contains an N-terminal PRDI-BF1 and RIZ homology (PR) domain, a SET domain, and three C-terminal C2H2 zinc finger DNA-binding domains. Naturally occurring mutations in this gene are associated with congenital insensitivity to pain (CIP), and hereditary sensory and autonomic neuropathies (HSAN's) affecting peripheral sensory and autonomic neurons. Deregulation of this gene is associated with solid cancers and hematological malignancies including chronic myeloid leukemia.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: PR domain containing 12; PR domain zinc finger protein 12; PR domain-containing protein 12; PR-domain containing protein 12; PR-domain zinc finger protein 12; RP11-57C19.7
Gene Aliases: Gm998; HSAN8; PFM9; PRDM12
UniProt ID: (Human) Q9H4Q4, (Mouse) A2AJ77
Entrez Gene ID: (Human) 59335, (Mouse) 381359
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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