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Product Details
H00010942-D01P
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PRSS21 (NP_006790.1, 1 a.a. approximately 314 a.a) full-length human protein.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MGARGALLLA LLLARAGLRK PESQEAAPLS GPCGRRVITS RIVGGEDAEL GRWPWQGSLR LWDSHVCGVS LLSHRWALTA AHCFETYSDL SDPSGWMVQF GQLTSMPSFW SLQAYYTRYF VSNIYLSPRY LGNSPYDIAL VKLSAPVTYT KHIQPICLQA STFEFENRTD CWVTGWGYIK EDEALPSPHT LQEVQVAIIN NSMCNHLFLK YSFRKDIFGD MVCAGNAQGG KDACFGDSGG PLACNKNGLW YQIGVVSWGV GCGRPNRPGV YTNISHHFEW IQKLMAQSGM SQPDPSWPLL FFPLLWALPL LGPV
Target Information
PRSS21, also known as testisin, is a serine protease gene located on human chromosome 16p13.3. This gene is primarily expressed in the testes, where it plays a significant role in spermatogenesis, particularly during the development and maturation of sperm cells. Structurally, PRSS21 encodes a glycosylphosphatidylinositol (GPI)-anchored serine protease, a feature that helps localize it to the cell surface, facilitating its involvement in cell signaling and proteolytic pathways. While research into PRSS21 remains ongoing, its specific function is believed to be related to remodeling the extracellular matrix during sperm development, impacting fertility. Beyond reproductive roles, alterations in PRSS21 expression have been observed in some cancer types, such as testicular germ cell tumors, suggesting its potential role as a biomarker for certain malignancies. This dual functionality underscores its importance not only in reproductive biology but also within oncology research.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 3.4.21; Eosinophil serine protease 1; ESP-1; protease, serine, 21 (testisin); Serine protease 21; serine protease from eosinophils; TEST1testisin; testicular serine protease 5; Testisin; Tryptase 4
Gene Aliases: 1700023E12Rik; ESP-1; ESP1; mT4; PRSS21; TESP5; TEST1; TESTISIN; UNQ266/PRO303
UniProt ID: (Human) Q9Y6M0, (Mouse) Q9JHJ7
Entrez Gene ID: (Human) 10942, (Mouse) 57256
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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