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Application
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PRSS21 Antibody (PA5-47879) in IHC (F)
Immunohistochemical analysis of PRSS21 in perfusion fixed frozen sections of mouse testis. Samples were incubated in PRSS21 polyclonal antibody (Product # PA5-47879) using a dilution of 1.7 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Specific staining was localized to the plasma membranes of spermatocy... View More
Product Details
PA5-47879
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Published species
Horse,
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse Testisin/Prss21 Gln28-Asn298
Conjugate
Unconjugated
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2577163
Product Specific Information
This antibody detects recombinant mouse Testisin/Prss21 in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant mouse (rm) Prss8 and rmPrss27 is observed.
Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.
Target Information
PRSS21, also known as testisin, is a serine protease gene located on human chromosome 16p13.3. This gene is primarily expressed in the testes, where it plays a significant role in spermatogenesis, particularly during the development and maturation of sperm cells. Structurally, PRSS21 encodes a glycosylphosphatidylinositol (GPI)-anchored serine protease, a feature that helps localize it to the cell surface, facilitating its involvement in cell signaling and proteolytic pathways. While research into PRSS21 remains ongoing, its specific function is believed to be related to remodeling the extracellular matrix during sperm development, impacting fertility. Beyond reproductive roles, alterations in PRSS21 expression have been observed in some cancer types, such as testicular germ cell tumors, suggesting its potential role as a biomarker for certain malignancies. This dual functionality underscores its importance not only in reproductive biology but also within oncology research.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EC 3.4.21; eosinophil serine protease-1; protease, serine, 21; Serine protease 21; TEST1testisin; testicular serine protease 5; Testisin; Tryptase 4
Gene Aliases: 1700023E12Rik; Esp-1; mT4; Prss21; Resp-1; TESP5; testisin
UniProt ID: (Mouse) Q9JHJ7
Entrez Gene ID: (Rat) 353251, (Mouse) 57256
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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