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Abnova
PRSS21 Monoclonal Antibody (2E10)
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Product Details
H00010942-M01
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
2E10
Immunogen
PRSS21 (NP_006790, 121 a.a. approximately 220 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: VSNIYLSPRY LGNSPYDIAL VKLSAPVTYT KHIQPICLQA STFEFENRTD CWVTGWGYIK EDEALPSPHT LQEVQVAIIN NSMCNHLFLK YSFRKDIFGD
Target Information
PRSS21, also known as testisin, is a serine protease gene located on human chromosome 16p13.3. This gene is primarily expressed in the testes, where it plays a significant role in spermatogenesis, particularly during the development and maturation of sperm cells. Structurally, PRSS21 encodes a glycosylphosphatidylinositol (GPI)-anchored serine protease, a feature that helps localize it to the cell surface, facilitating its involvement in cell signaling and proteolytic pathways. While research into PRSS21 remains ongoing, its specific function is believed to be related to remodeling the extracellular matrix during sperm development, impacting fertility. Beyond reproductive roles, alterations in PRSS21 expression have been observed in some cancer types, such as testicular germ cell tumors, suggesting its potential role as a biomarker for certain malignancies. This dual functionality underscores its importance not only in reproductive biology but also within oncology research.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 3.4.21; Eosinophil serine protease 1; ESP-1; protease, serine, 21 (testisin); Serine protease 21; serine protease from eosinophils; TEST1testisin; Testisin
Gene Aliases: ESP-1; ESP1; PRSS21; TEST1; TESTISIN; UNQ266/PRO303
UniProt ID: (Human) Q9Y6M0
Entrez Gene ID: (Human) 10942
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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