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Immunogen sequence: MSIMSYNGGA VMAMKGKNCV AIAADRRFGI QAQMVTTDFQ KIFPMGDRLY IGLAGLATDV QTVAQRLKFR LNLYELKEGR QIKPYTLMSM VANLLYEKRF GPYYTEPVIA GLDPKTFKPF ICSLDLIGCP MVTDDFVVSG TCAEQMYGMC ESLWEPNMDP DHLFETISQA MLNAVDRDAV SGMGVIVHII EKDKITTRTL KARMD; Positive Samples: NIH/3T3, MCF-7, HeLa, Jurkat, Mouse brain, Rat liver, Rat brain; Cellular Location: Cytoplasm, Nucleus
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Pseudogenes have been identified on chromosomes 2 and 12.
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Protein Aliases: MGC4147; proteasome (prosome, macropain) subunit, beta type, 3; proteasome beta 3 subunit; Proteasome chain 13; Proteasome component C10-II; Proteasome subunit beta type-3; Proteasome theta chain
Gene Aliases: AL033320; C10-II; HC10-II; PSMB3
UniProt ID: (Human) P49720, (Mouse) Q9R1P1, (Rat) P40112
Entrez Gene ID: (Human) 5691, (Mouse) 26446, (Rat) 29676
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