Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MYEQLKGEWN RKSPNLSKCG EELGRLKLVL LELNFLPTTG TKLTKQQLIL ARDILEIGAQ WSILRKDIPS FERYMAQLKC YYFDYKEQLP ESAYMHQLLG LNLLFLLSQN RVAEFHTELE RLPAKDIQTN VYIKHPVSLE QYLMEGSYNK VFLAKGNIPA ESYTFFIDIL LDTIRDEIAG CIEKAYEKIL FTEATRILFF NTPKKMTDYA KKRGWVLGPN NYYSFASQQQ KPEDTTIPST ELAKQVIEYA RQLEMIV
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 26S proteasome non-ATPase regulatory subunit 8; 26S proteasome regulatory subunit p31; 26S proteasome regulatory subunit RPN12; 26S proteasome regulatory subunit S14; epididymis secretory sperm binding protein Li 91n; p31; proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
Gene Aliases: HEL-S-91n; HIP6; HYPF; Nin1p; p31; PSMD8; Rpn12; S14
UniProt ID: (Human) P48556
Entrez Gene ID: (Human) 5714
Molecular Function:
protease
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