Product References
A p53-phosphoinositide signalosome regulates nuclear AKT activation.
Nature cell biology
Chen M,Choi S,Wen T,Chen C,Thapa N,Lee JH,Cryns VL,Anderson RA
MA5-12278 was used in Immunocytochemistry and Western Blotting to show that genotoxic stress induces nuclear AKT activation through a p53-dependent mechanism that is distinct from the canonical membrane-localized PI3K-AKT pathway.
Fri Jul 01 00:00:00 EDT 2022
A p53-phosphoinositide signalosome regulates nuclear AKT activation.
Nature cell biology
Chen M,Choi S,Wen T,Chen C,Thapa N,Lee JH,Cryns VL,Anderson RA
MA5-12278 was used in Immunocytochemistry and Western Blotting to show that genotoxic stress induces nuclear AKT activation through a p53-dependent mechanism that is distinct from the canonical membrane-localized PI3K-AKT pathway.
Fri Jul 01 00:00:00 EDT 2022
A p53-phosphoinositide signalosome regulates nuclear AKT activation.
Nature cell biology
Chen M,Choi S,Wen T,Chen C,Thapa N,Lee JH,Cryns VL,Anderson RA
MA5-12278 was used in Immunocytochemistry and Western Blotting to show that genotoxic stress induces nuclear AKT activation through a p53-dependent mechanism that is distinct from the canonical membrane-localized PI3K-AKT pathway.
Fri Jul 01 00:00:00 EDT 2022
WP1066 induces cell death in a schwannomatosis patient-derived schwannoma cell line.
Cold Spring Harbor molecular case studies
Allaf A,Victoria B,Rosario R,Misztal C,Humayun Gultekin S,Dinh CT,Fernandez-Valle C
MA5-12278 was used in Western Blotting to demonstrate feasibility in creating patient-derived cell lines for use in precision medicine studies.
Wed Jun 01 00:00:00 EDT 2022
A study on promoter methylation of PTEN in sporadic breast cancer patients from North India.
Breast cancer (Tokyo, Japan)
Siddiqui S,Akhter N,Deo SV,Shukla NK,Husain SA
MA512278 was used in immunohistochemistry - paraffin section to evaluate the contribution of PTEN promoter methylation to sporadic breast cancer in patients from North India
Tue Nov 01 00:00:00 EDT 2016
Serous carcinoma arising from uterine adenomyosis/adenomyotic cyst of the cervical stump: a report of 3 cases.
Diagnostic pathology
Lu B,Chen Q,Zhang X,Cheng L
MA5-12278 was used in immunohistochemistry to study 3 cases of uterine adenomyosis/adenomyotic cysts of the cervical stump leading to serous carcinoma
Sat Jun 04 00:00:00 EDT 2016
Immunopathologic Assessment of PTEN Expression.
Methods in molecular biology (Clifton, N.J.)
Castillo-Martin M,Thin TH,Collazo Lorduy A,Cordon-Cardo C
MA5-12278 was used in immunohistochemistry - paraffin section to assess PTEN expression by immunopathology
Tue Dec 13 00:00:00 EST 2016
IDH-mutant glioma specific association of rs55705857 located at 8q24.21 involves MYC deregulation.
Scientific reports
Oktay Y,Ülgen E,Can Ö,Akyerli CB,Yüksel Ş,Erdemgil Y,Durası IM,Henegariu OI,Nanni EP,Selevsek N,Grossmann J,Erson-Omay EZ,Bai H,Gupta M,Lee W,Turcan Ş,Özpınar A,Huse JT,Sav MA,Flanagan A,Günel M,Sezerman OU,Yakıcıer MC,Pamir MN,Özduman K
MA512278 was used in immunohistochemistry to describe the mechanism behind the association between single nucleotide polymorphism rs55705857 and glioma development.
Fri Jun 10 00:00:00 EDT 2016
Modeling glands with PTEN deficient cells and microscopic methods for assessing PTEN loss: endometrial cancer as a model.
Methods (San Diego, Calif.)
Eritja N,Santacana M,Maiques O,Gonzalez-Tallada X,Dolcet X,Matias-Guiu X
MA5-12278 was used in immunohistochemistry use endometrial carcinoma as a three-dimensional model to study PTEN deficiency
Fri May 01 00:00:00 EDT 2015
Identification of prognostic biomarkers for glioblastomas using protein expression profiling.
International journal of oncology
Jung Y,Joo KM,Seong DH,Choi YL,Kong DS,Kim Y,Kim MH,Jin J,Suh YL,Seol HJ,Shin CS,Lee JI,Kim JH,Song SY,Nam DH
MA5-12278 was used in immunohistochemistry - paraffin section to identify diagnostic and prognostic markers for glioblastoma
Sun Apr 01 00:00:00 EDT 2012
Analysis of the concordance in the EGFR pathway status between primary tumors and related metastases of colorectal cancer patients:implications for cancer therapy.
Current cancer drug targets
Cejas P,López-Gómez M,Aguayo C,Madero R,Moreno-Rubio J,de Castro Carpeño J,Belda-Iniesta C,Barriuso J,Moreno García V,Díaz E,Burgos E,Gonzalez-Barón M,Feliu J
MA5-12278 was used in immunohistochemistry to study EGFR signaling pathway components in primary colorectal cancer and paired metastases
Wed Feb 01 00:00:00 EST 2012
Prognostic impact of concomitant p53 and PTEN on outcome in early stage (FIGO I-II) epithelial ovarian cancer.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
Skírnisdóttir I,Seidal T
MA5-12278 was used in immunohistochemistry to investigate the effectiveness of PTEN and p53 for the prognosis of ovarian carcinomas
Mon Aug 01 00:00:00 EDT 2011
Prevalence and prognostic influence of genomic changes of EGFR pathway markers in synovial sarcoma.
Journal of surgical oncology
Teng HW,Wang HW,Chen WM,Chao TC,Hsieh YY,Hsih CH,Tzeng CH,Chen PC,Yen CC
MA5-12278 was used in immunohistochemistry to study the potential prognostic value of EGFR pathway markers in synovial sarcoma
Wed Jun 01 00:00:00 EDT 2011
Chronic lymphocytic leukemia modeled in mouse by targeted miR-29 expression.
Proceedings of the National Academy of Sciences of the United States of America
Santanam U,Zanesi N,Efanov A,Costinean S,Palamarchuk A,Hagan JP,Volinia S,Alder H,Rassenti L,Kipps T,Croce CM,Pekarsky Y
MA5-12278 was used in western blot to study the role of miR-29 in B-cell chronic lymphocytic leukemia
Tue Jul 06 00:00:00 EDT 2010
PIK3CA mutations mostly begin to develop in ductal carcinoma of the breast.
Experimental and molecular pathology
Li H,Zhu R,Wang L,Zhu T,Li Q,Chen Q,Wang H,Zhu H
MA5-12278 was used in immunohistochemistry to study PIK3CA mutations in ductal carcinoma of the breast
Mon Feb 01 00:00:00 EST 2010
Phase II study of preoperative systemic treatment with the combination of docetaxel and trastuzumab in patients with locally advanced HER-2-overexpressing breast cancer.
Breast (Edinburgh, Scotland)
Sawaki M,Iwata H,Sato Y,Wada M,Toyama T,Sasaki E,Yatabe Y,Imai T,Ohashi Y
MA5-12278 was used in immunohistochemistry to investigate the efficacy of docetaxel and trastuzumab against locally advanced HER-2-overexpressing breast cancer
Fri Oct 01 00:00:00 EDT 2010
Physiological PTEN expression in peripheral T-cell lymphoma not otherwise specified.
Haematologica
Gazzola A,Bertuzzi C,Agostinelli C,Righi S,Pileri SA,Piccaluga PP
MA5-12278 was used in immunohistochemistry to study the level of PTEN in peripheral T-cell lymphoma
Wed Jul 01 00:00:00 EDT 2009
Comparison of placental PTEN and beta1 integrin expression in early spontaneous abortion, early and late normal pregnancy.
Upsala journal of medical sciences
Tokyol C,Aktepe F,Hüsniye Dilek F,Yilmazer M
MA5-12278 was used in immunohistochemistry to investigate the changes of PTEN and beta1 integrin in different stages of pregnancy and pregnancy termination
Mon Aug 11 00:00:00 EDT 2008
PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research
Pérez-Tenorio G,Alkhori L,Olsson B,Waltersson MA,Nordenskjöld B,Rutqvist LE,Skoog L,Stål O
MA5-12278 was used in immunohistochemistry to examine the role of PIK3CA mutations and PTEN loss in the carcinogenesis of breast cells
Fri Jun 15 00:00:00 EDT 2007
Epidermal growth factor ligand/receptor loop and downstream signaling activation pattern in completely resected nonsmall cell lung cancer.
Cancer
Volante M,Saviozzi S,Rapa I,Ceppi P,Cappia S,Calogero R,Novello S,Borasio P,Papotti M,Scagliotti GV
MA5-12278 was used in immunohistochemistry to study EGF receptor pathway activation in completely resected non-small cell lung cancer
Sat Sep 15 00:00:00 EDT 2007
Immunohistochemical expression of PTEN in normal, hyperplastic and malignant endometrium and its correlation with hormone receptors, bcl-2, bax, and apoptotic index.
Pathology, research and practice
Kapucuoglu N,Aktepe F,Kaya H,Bircan S,Karahan N,Ciriş M
MA5-12278 was used in immunohistochemistry to investigate the expression of PTEN in normal, hyperplastic and malignant endometrium
Fri May 04 00:00:00 EDT 2007
Loss of neutral endopeptidase and activation of protein kinase B (Akt) is associated with prostate cancer progression.
Cancer
Osman I,Dai J,Mikhail M,Navarro D,Taneja SS,Lee P,Christos P,Shen R,Nanus DM
MA5-12278 was used in immunohistochemistry to examine the involvement of neutral endopeptidase in prostate cancer progression
Fri Dec 01 00:00:00 EST 2006
Significance of Survivin and PTEN expression in full lymph node-examined gastric cancer.
World journal of gastroenterology
Deng H,Wu RL,Zhou HY,Huang X,Chen Y,Liu LJ
MA5-12278 was used in immunohistochemistry to study the relationship between survivin and PTEN expression and prognosis in gastric cancer
Tue Feb 21 00:00:00 EST 2006
PTEN mutation, expression and LOH at its locus in ovarian carcinomas. Relation to TP53, K-RAS and BRCA1 mutations.
Gynecologic oncology
Kolasa IK,Rembiszewska A,Janiec-Jankowska A,Dansonka-Mieszkowska A,Lewandowska AM,Konopka B,Kupryjańczyk J
MA5-12278 was used in immunohistochemistry to study the role of PTEN mutations in low-grade endometrioid tumors
Wed Nov 01 00:00:00 EST 2006
Protein expression and prognostic value of genes in the erb-b signaling pathway in advanced ovarian carcinomas.
American journal of clinical pathology
Wang Y,Kristensen GB,Helland A,Nesland JM,Børresen-Dale AL,Holm R
MA5-12278 was used in immunohistochemistry to study the prognostic value of the erb-b signaling pathway in advanced ovarian carcinomas
Thu Sep 01 00:00:00 EDT 2005
The role of PTEN and its signalling pathways, including AKT, in breast cancer; an assessment of relationships with other prognostic factors and with outcome.
The Journal of pathology
Panigrahi AR,Pinder SE,Chan SY,Paish EC,Robertson JF,Ellis IO
MA5-12278 was used in immunohistochemistry to study the role of PTEN signaling pathways in breast cancer
Wed Sep 01 00:00:00 EDT 2004
Proliferation kinetics in adenomyosis during the menstrual cycle and during oral contraceptive use.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
Maia H,Maltez A,Studart E,Athayde C,Coutinho EM
MA5-12278 was used in immunohistochemistry to study the expression of p53 in adenomyosis during the menstrual cycle and during oral contraceptive use
Sun Feb 01 00:00:00 EST 2004