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            • Primary Antibodies ›
            • STEP Antibodies

            Abnova

            PTPN5 Monoclonal Antibody (2H5)

            View all (9) STEP antibodies
            Datasheet
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            Catalog # H00084867-M03
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            Price (USD)
            465.00
            100 µg
             
            Estimated availability date: 12-Jun-2025
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            Cite PTPN5 Monoclonal Antibody (2H5)

            • Antibody Testing Data (1)
            Application
            PTPN5 Antibody in Immunoprecipitation (IP)
            Group 53 Created with Sketch.

            FIGURE: 1 / 1

            PTPN5 Antibody (H00084867-M03) in IP

            Immunoprecipitation of PTPN5 transfected lysate using anti-PTPN5 monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with PTPN5 MaxPab rabbit polyclonal antibody.
            View Product

            PTPN5 Antibody in Immunoprecipitation (IP)

            Product Details

            H00084867-M03

            Applications
            Tested Dilution
            Publications

            ELISA (ELISA)

            10 µg/mL
            -

            Immunoprecipitation (IP)

            1-5 µg/mL
            -
            Product Specifications

            Species Reactivity

            Human

            Host/Isotype

            Mouse / IgG1, kappa

            Class

            Monoclonal

            Type

            Antibody

            Clone

            2H5

            Immunogen

            PTPN5 (NP_116170, 388 a.a. approximately 486 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
            View immunogen

            Conjugate

            Unconjugated

            Form

            Liquid

            Concentration

            0.5 mg/mL

            Purification

            Protein A

            Storage buffer

            PBS, pH 7.4

            Contains

            no preservative

            Storage conditions

            -20°C, Avoid Freeze/Thaw Cycles

            Shipping conditions

            Ambient (domestic); Wet ice (international)

            Product Specific Information

            Immunogen sequence: WQEHTPIIVM ITNIEEMNEK CTEYWPEEQV AYDGVEITVQ KVIHTEDYRL RLISLKSGTE ERGLKHYWFT SWPDQKTPDR APPLLHLVRE VEEAAQQEG

            Target Information

            Reversible phosphorylation of tyrosine residues is a key regulatory mechanism for numerous cellular events such as proliferation, differentiation, gene expression and migration. Abnormalities in tyrosine phosphorylation play a role in the pathogenesis of numerous inherited or acquired human diseases from cancer to immune deficiencies. There are at least 107 genes coding for PTPs (protein tyrosine phosphatases) in the human genome. All known PTPs contain a highly conserved 12 amino acid catalytic domain and are further distinguished on the basis of additional structural motifs. The receptor-like PTPs exhibit an extracellular domain, a single transmembrane and one or two intracellular phosphatase domains. The nonreceptor cytoplasmic PTPs contain a single phosphatase domain and additional amino acid sequences that are homologous to motifs found in other classes of proteins. Protein tyrosine phosphatases PTPN5 (STEP), PTPRR and PTPN7 comprise a family of phosphatases that specifically inactivate MAPKs (mitogen-activated protein kinases). There are multiple forms of STEP in the adult rat brain which show differential enrichment in brain regions implicated in aspects of cognitive, affective, and motor behaviors. Some of the STEP isoforms are generated through alternative splicing of a single STEP gene and each has unique intracellular targets and functions.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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            Cite this product

            Bioinformatics

            Protein Aliases: FLJ14427; Neural-specific protein-tyrosine phosphatase; protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched); protein-tyrosine phosphatase striatum-enriched; PTN5; PTP STEP; PTPN 5; STEP; striatal-enriched protein tyrosine phosphatase; Striatum-enriched protein-tyrosine phosphatase; Tyrosine-protein phosphatase non-receptor type 5

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            Gene Aliases: PTPN5; PTPSTEP; STEP; STEP61

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            UniProt ID: (Human) P54829

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            Entrez Gene ID: (Human) 84867

            View more View less

            Function(s)

            phosphotyrosine binding protein tyrosine phosphatase activity protein binding glutamate receptor binding mitogen-activated protein kinase binding

            Process(es)

            positive regulation of protein phosphorylation response to amphetamine positive regulation of receptor internalization protein dephosphorylation positive regulation of neuron projection development positive regulation of protein import into nucleus, translocation peptidyl-tyrosine dephosphorylation exploration behavior response to immobilization stress response to drug negative regulation of MAP kinase activity positive regulation of long-term synaptic potentiation positive regulation of neuron death response to acetylsalicylate positive regulation of protein targeting to mitochondrion positive regulation of response to drug
            It has to be done as per old AB suggested Products section.
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