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PYDC1 Antibody (MA5-26607) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded adenocarcinoma of human colon tissue. To expose target proteins, 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min was used. Following antigen retrieval, tissues were probed with a PYDC1 monoclonal antibody (Product # MA5-26607).
Product Details
MA5-26607
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI9E12
Immunogen
Full length human recombinant protein of PYDC1 produced in E.coli
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2723918
Target Information
ASC2 associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. It suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cellular POP1; cPOP1; PAAD-only protein 1; PYD (pyrin domain) containing 1; Pyrin domain-containing protein 1; Pyrin-only protein 1
Gene Aliases: ASC2; ASCI; cPOP1; POP1; PYC1; PYDC1
UniProt ID: (Human) Q8WXC3
Entrez Gene ID: (Human) 260434
activation of innate immune response
positive regulation of defense response to virus by host
myeloid dendritic cell activation involved in immune response
positive regulation of antigen processing and presentation of peptide antigen via MHC class II
negative regulation of protein kinase activity
activation of cysteine-type endopeptidase activity involved in apoptotic process
inflammatory response
response to bacterium
regulation of autophagy
negative regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of actin filament polymerization
regulation of protein stability
negative regulation of NF-kappaB transcription factor activity
interleukin-1 beta production
positive regulation of interferon-gamma production
positive regulation of interleukin-6 production
tumor necrosis factor-mediated signaling pathway
positive regulation of activated T cell proliferation
regulation of GTPase activity
macropinocytosis
innate immune response
negative regulation of interleukin-1 beta secretion
positive regulation of interleukin-1 beta secretion
regulation of inflammatory response
positive regulation of phagocytosis
positive regulation of ERK1 and ERK2 cascade
positive regulation of chemokine secretion
activation of cysteine-type endopeptidase activity
negative regulation of NLRP3 inflammasome complex assembly
positive regulation of T cell migration
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