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Rockland
Penicillinase Polyclonal Antibody
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Product Details
100-4175
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bacteria
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Penicillinase [Enterobacter cloacae]
Conjugate
Unconjugated
Form
Lyophilized
Concentration
90 mg/mL
Storage buffer
0.01M sodium phosphate/whole serum, pH 7.2, with 0.15M NaCl
Contains
0.01% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Store vial at 4° C prior to restoration. For extended storage aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-rabbit serum, purified and partially purified Penicillinase [Enterobacter cloacae]. Cross reactivity against Penicillinase from other tissues and species may occur but have not been specifically determined.
Target Information
Penicillinase, also known as beta-lactamase, is an enzyme produced by certain bacteria that confers resistance to penicillin and other beta-lactam antibiotics. This enzyme works by hydrolyzing the beta-lactam ring of penicillin, rendering the antibiotic ineffective in inhibiting bacterial cell wall synthesis. Penicillinase is encoded by various bacterial genes, commonly found in plasmids or chromosomes, which can be transferred between bacteria, leading to the spread of antibiotic resistance. This enzyme is a significant concern in treating bacterial infections, as it diminishes the efficacy of beta-lactam antibiotics, which are widely used in clinical settings. The presence of penicillinase-producing bacteria necessitates the use of alternative antibiotics or combination therapies that include beta-lactamase inhibitors, such as clavulanic acid, to restore the antibiotic's effectiveness. Monitoring and studying penicillinase activity are crucial for managing antibiotic resistance and developing new therapeutic strategies to combat resistant bacterial strains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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