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Proteintech
Pepsinogen I Polyclonal Antibody
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Product Details
17330-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Pepsinogen I Fusion Protein Ag11309 (1-388 aa encoded by BC029055)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.23 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody can recognize PGA3 (pepsinogen 3), PGA4(pepsinogen 4), PGA5(pepsinogen 5).
Immunogen sequence: MKWLLLLGL VALSECIMYK VPLIRKKSLR RTLSERGLLK DFLKKHNLNP ARKYFPQWEA PTLVDEQPLE NYLDMEYFGT IGIGTPAQDF TVVFDTGSSN LWVPSVYCSS LACTNHNRFN PEDSSTYQST SETVSITYGT GSMTGILGYD TVQVGGISDT NQIFGLSETE PGSFLYYAPF DGILGLAYPS ISSSGATPVF DNIWNQGLVS QDLFSVYLSA DDKSGSVVIF GGIDSSYYTG SLNWVPVTVE GYWQITVDSI TMNGETIACA EGCQAIVDTG TSLLTGPTSP IANIQSDIGA SENSDGDMVV SCSAISSLPD IVFTINGVQY PVPPSAYILQ SEGSCISGFQ GMNVPTESGE LWILGDVFIR QYFTVFDRAN NQVGLAPVA (1-388 aa encoded by BC029055 )
Target Information
PGA5: Pepsinogen 5, group I (pepsinogen A). Pepsinogens are the inactive precursors of pepsin, the major acid protease found in the stomach. Pepsin is one of the main proteolytic enzymes secreted by the gastric mucosa. Pepsin consists of a single polypeptide chain and arises from its precursor, pepsinogen, by removal of a 41 amino acid segment from the N-terminus. Pepsinogen is synthesized in the stomach lining, and hydrochloric acid, also produced by the gastric mucosa, is necessary to convert the inactive enzyme and to maintain the optimum acidity (pH 1-3) for pepsin function. Pepsin is particularly effective in cleaving peptide bonds involving aromatic amino acids. Pepsin shows extremely broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. PGA5 is a member of the subfamily A1 within the pepsin family and is the predominant endopeptidase in the gastric juice of vertebrates. PGA5 is inhibited by ovUS-1, a uterine serpin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: pepsin A; Pepsin A-5; Pepsin F; pepsinogen 5, group I; pepsinogen 5, group I (pepsinogen A); pepsinogen A5; pepsinogen F; pepsinogen F protein; Pepsinogen-5
Gene Aliases: 1110035E17Rik; Pepf; Pg5; PGA5
UniProt ID: (Human) P0DJD9, (Mouse) Q9D106
Entrez Gene ID: (Human) 5222, (Mouse) 58803, (Rat) 60372
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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