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QED Bioscience
Phenobarbital is a long-acting barbituric acid derivative with antipsychotic property. Phenobarbital binds to and activates the gamma-aminobutyric acid (GABA)-A receptor, thereby mimicking the inhibitory actions of GABA in the brain. The activation effects of the phenobarbital-receptor-ionophore complex include increased frequency of chloride channel openings, membrane hyperpolarization and ultimately synaptic inhibition and decreased neuronal excitability. In addition, this agent inhibits glutamate induced depolarization. [National Center for Biotechnology Information. PubChem Compound Database; CID=4763].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C12H12N2O3; Luminal; Phenobarbitol; Phenobarbitone; Phenylethylbarbiturate
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