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Phospho-53BP2 (Ser698) Antibody (PA5-105070) in WB
Western blot analysis of Phospho-53BP2 (Ser698) in extracts from various samples. Samples were incubated with Phospho-53BP2 (Ser698) polyclonal antibody (Product # PA5-105070). Lane 1: 3t3-l1 cells (heat-shock treatment), blocked with antigen-specific peptides; Lane 2: 3t3-l1 cells (heat-shock treatment); Lane 3: K562 cells (heat-shock treatment).
Product Details
PA5-105070
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TP53BP2(Accession Q13625), corresponding to amino acid residues around phosphorylated Ser698.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2816543
Product Specific Information
Antibody detects endogenous levels of ASPP2 only when phosphorylated at Ser698.
Target Information
Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 53BP2; Apoptosis-stimulating of p53 protein 2; apoptosis-stimulating protein of p53, 2; Bbp; BCL2-binding protein; P PPP1R13A; Renal carcinoma antigen NY-REN-51; transformation related protein 53 binding protein 2; tumor protein p53 binding protein, 2; Tumor suppressor p53-binding protein 2
Gene Aliases: 53BP2; ASPP2; BBP; P53BP2; PPP1R13A; TP53BP2; Trp53bp2
UniProt ID: (Human) Q13625
Entrez Gene ID: (Human) 7159, (Rat) 305025
cell cycle
signal transduction
regulation of apoptotic process
negative regulation of cell cycle
intrinsic apoptotic signaling pathway by p53 class mediator
positive regulation of execution phase of apoptosis
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
positive regulation of neuron death
regulation of signal transduction by p53 class mediator
central nervous system development
heart development
biological_process
embryo development ending in birth or egg hatching
response to ionizing radiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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