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Antibody detects endogenous levels of CtIP only when phosphorylated at Ser327.
CtIP, a 125 kD protein, was originally found interacting with a transcription repressor, CtBP, through the PLDLS motif (CtBP-Interacting Protein) thus suggested a role in transcription. Studies have shown that CtIP also interacts with BRCA1 protein through the c-terminus BRCT domains also suggested that CtIP is a potential tumor suppressor. This CtIP-BRCA1 interaction can be disrupted by DNA damaging agents including UV or gamma-irradiation. Li et al (Nature 406, 210 - 215 (2000)) have shown that ATM phosphorylates CtIP at serine residues 664 and 745, and mutation of these sites abrogates the dissociation of BRCA1 from CtIP, resulting in persistent repression of BRCA1-dependent induction of GADD45 upon ionizing radiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CTBP-interacting protein; CtIP; DNA endonuclease RBBP8; RBBP-8; retinoblastoma binding protein 8; Retinoblastoma-binding protein 8; Retinoblastoma-interacting protein and myosin-like; RIM; SAE2; Sporulation in the absence of SPO11 protein 2 homolog
Gene Aliases: 9930104E21Rik; COM1; CTIP; JWDS; RBBP-8; RBBP8; RGD1308872; RIM; SAE2; SCKL2
UniProt ID: (Human) Q99708, (Rat) B1WC58, (Mouse) Q80YR6
Entrez Gene ID: (Human) 5932, (Rat) 291787, (Mouse) 225182
Molecular Function:
transcription cofactor
gene-specific transcriptional regulator
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