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Phospho-Cullin 4A (Ser40) Antibody (PA5-105313) in ICC/IF
Immunofluorescent analysis of Phospho-Cullin 4A (Ser40) in HeLa cells(4h of LPS treatment). Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and Phospho-Cullin 4A (Ser40) polyclonal antibody (Product # PA5-105313) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fl... View More
Product Details
PA5-105313
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CUL4A(Accession Q13619), corresponding to amino acid residues around phosphorylated Ser40.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2816741
Product Specific Information
Antibody detects endogenous levels of CUL4A only when phosphorylated at Ser40.
Target Information
CUL4A (Cullin 4A) is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CUL 4A; CUL-4A; Cul4a protein; Cullin-4A; MGC36573; MGC64071; OTTHUMP00000018753
Gene Aliases: 2810470J21Rik; AW495282; CUL4A; RGD1563853
UniProt ID: (Human) Q13619, (Mouse) Q3TCH7
Entrez Gene ID: (Human) 8451, (Mouse) 99375, (Rat) 361181
G1/S transition of mitotic cell cycle
nucleotide-excision repair, DNA damage recognition
nucleotide-excision repair, DNA duplex unwinding
in utero embryonic development
transcription-coupled nucleotide-excision repair
nucleotide-excision repair, preincision complex stabilization
nucleotide-excision repair, preincision complex assembly
nucleotide-excision repair, DNA incision, 3'-to lesion
nucleotide-excision repair, DNA incision, 5'-to lesion
cellular response to DNA damage stimulus
cell cycle arrest
positive regulation of cell proliferation
negative regulation of cell proliferation
viral process
hemopoiesis
negative regulation of granulocyte differentiation
nucleotide-excision repair, DNA incision
somatic stem cell population maintenance
DNA damage response, detection of DNA damage
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of protein metabolic process
global genome nucleotide-excision repair
intrinsic apoptotic signaling pathway
positive regulation of G1/S transition of mitotic cell cycle
regulation of DNA damage checkpoint
regulation of nucleotide-excision repair
DNA repair
ubiquitin-dependent protein catabolic process
positive regulation of protein catabolic process
Performance Guarantee
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