Invitrogen

Phospho-FGFR4 (Tyr642) Polyclonal Antibody

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1 Reference
View all (34) FGFR4 antibodies
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Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

PA5-105531

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human FGFR4(Accession P22455), corresponding to amino acid residues around phosphorylated Tyr642.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2816959

Product Specific Information

Antibody detects endogenous levels of FGFR4 only when phosphorylated at Tyr642.

Target Information

FGFR4 is a member of the FGFR family of receptor tyrosine kinases. This family is known to regulate a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR family has also been implicated in a number of diseases including cancer, rheumatoid arthritis, and diabetic retinopathy. FGFR4 is required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. FGFR4 plays a role in postnatal lung development and may be involved in the development of skeletal muscle cell lineages.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: CD334; CTLA-2-beta protein; FGF Receptor; FGF Receptor 4; FGFR; FGFR-4; Fibroblast growth factor receptor 4; fibroblast growth factor receptor 4 16 minus form; hydroxyaryl-protein kinase; MGC20292; protein-tyrosine kinase; Protein-tyrosine kinase receptor MPK-11; tyrosine kinase related to fibroblast growth factor receptor; tyrosylprotein kinase

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Gene Aliases: CD334; Fgfr-4; FGFR4; JTK2; Mpk-11; TKF

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UniProt ID: (Human) P22455, (Rat) Q498D6, (Mouse) Q03142

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Entrez Gene ID: (Human) 2264, (Rat) 25114, (Mouse) 14186

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Function(s)
protein tyrosine kinase activity fibroblast growth factor-activated receptor activity Ras guanyl-nucleotide exchange factor activity protein binding ATP binding heparin binding 1-phosphatidylinositol-3-kinase activity fibroblast growth factor binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity nucleotide binding protein kinase activity transmembrane receptor protein tyrosine kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups transmembrane signal receptor
Process(es)
MAPK cascade positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway positive regulation of gene expression regulation of extracellular matrix disassembly regulation of phosphatidylinositol 3-kinase signaling cell migration peptidyl-tyrosine phosphorylation regulation of lipid metabolic process phosphatidylinositol-3-phosphate biosynthetic process glucose homeostasis positive regulation of catalytic activity positive regulation of GTPase activity positive regulation of proteolysis protein autophosphorylation phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling phosphate ion homeostasis positive regulation of ERK1 and ERK2 cascade regulation of bile acid biosynthetic process response to bile acid regulation of cholesterol homeostasis positive regulation of DNA biosynthetic process organ induction lung development alveolar secondary septum development protein phosphorylation phosphorylation
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