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Invitrogen
Phospho-LAT (Tyr255) Polyclonal Antibody
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Application
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Phospho-LAT (Tyr255) Antibody (PA5-106144) in WB
Western blot analysis of Phospho-LAT (Tyr255) in HepG2. Samples were incubated with Phospho-LAT (Tyr255) polyclonal antibody (Product # PA5-106144).
Product Details
PA5-106144
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human LAT(Accession O43561), corresponding to amino acid residues around phosphorylated Tyr255.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2817542
Product Specific Information
Antibody detects endogenous levels of LAT only when phosphorylated at Tyr255.
Target Information
LAT (Linker for Activation of T cells) is a 36-38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell- and FcepsilonRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 36 kDa phospho-tyrosine adapter protein; 36 kDa phospho-tyrosine adaptor protein; 36 kDa phosphotyrosine adapter protein; linker for activation of T cells; linker for activation of T cells, transmembrane adaptor; Linker for activation of T-cells family member 1; linker protein; p36-38; pp36
Gene Aliases: LAT; LAT1; pp36
UniProt ID: (Human) O43561, (Mouse) O54957, (Rat) O70601
Entrez Gene ID: (Human) 27040, (Mouse) 16797, (Rat) 81511
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