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This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms.
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Protein Aliases: 1 BAC CH230-300K22 (Children's Hospital Oakland Research Institute) complete; 47 kDa actin binding protein; 47 kDa actin-binding protein; 52 kDa phosphoprotein; F-actin binding and cytoskeleton associated protein; leufactin (leukocyte F-actin binding protein); leukocyte specific protein 1; leukocyte-specific protein 1; lsp; lymphocyte specific 1; lymphocyte specific protein 1; Lymphocyte-specific antigen WP34; Lymphocyte-specific protein 1; OTTHUMP00000014138; OTTHUMP00000069614; OTTHUMP00000069615; OTTHUMP00000069616; pp52; S37 protein
Gene Aliases: Lsp-1; LSP1; p50; Pp52; S37; WP34
UniProt ID: (Human) P33241, (Mouse) P19973
Entrez Gene ID: (Human) 4046, (Mouse) 16985, (Rat) 361680
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