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Bioss

Phospho-PI3 Kinase p110 beta (Ser1070) Polyclonal Antibody

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Catalog # BS-6417R

Price (USD)

364.65

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100 µL

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Datasheet

Protocols

Questions & Answers

Antibody Testing Data (3)

Application

Phospho-PI3 Kinase p110 beta (Ser1070) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 3

Phospho-PI3 Kinase p110 beta (Ser1070) Antibody (BS-6417R) in IHC (P)

Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti-phospho-PI3 Kinase p110 beta(Ser1070) Polyclonal Antibody, Unconjugated (bs-6417R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.

Phospho-PI3 Kinase p110 beta (Ser1070) Antibody in Western Blot (WB)

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Product Details

BS-6417R

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500

Immunocytochemistry (ICC/IF)

1:50-1:200

ELISA (ELISA)

1:500-1:1,000

Product Specifications

Species Reactivity

Dog, Human, Mouse, Rabbit, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic phosphopeptide derived from human PI3 Kinase p110 beta around the phosphorylation site of Ser1070.

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Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

PIK3CB (phosphatyidylinositol 4,5-biphosphate 3-kinase catalyic subunit beta isoform) is a phosphoinositide-3-kinase that phosphorylates PtdIns (phosphatidylinositol), PtdIns4P (phosphatidylinositol 4-phosphate), and PtdIns(4,5)P2 (phosphatidylinositol 4,5-biphosphate) to generate phosphatidylinositol 3,4,5-triphosphate (PIP3). PIP3 plays a key role in recruiting PH domain-containing proteins to the membrane and activating signaling cascades involved in cell growth, survival, proliferation, motility, and morphology.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: catalytic phosphatidylinositol 3-kinase beta; p110beta; phosphatidylinositol 3-kinase catalytic subunit beta isoform; phosphatidylinositol 3-kinase, catalytic subunit, beta isoform; phosphatidylinositol 3-kinase, catalytic, beta polypeptide; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; phosphoinositide-3-kinase, catalytic, beta polypeptide; PI3-kinase p110 subunit beta; PI3-kinase subunit beta; PI3K; PI3K-beta; PI3Kbeta; pi3kcb; PtdIns-3-kinase p110; ptdIns-3-kinase subunit beta; PtdIns-3-kinase subunit p110-beta; Serine/threonine protein kinase PIK3CB

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Gene Aliases: 1110001J02Rik; AI447572; P110BETA; PI3K; PI3KBETA; PIK3C1; PIK3CB

UniProt ID: (Human) P42338, (Mouse) Q8BTI9, (Rat) Q9Z1L0

Entrez Gene ID: (Human) 5291, (Dog) 477085, (Rabbit) 100345181, (Mouse) 74769, (Rat) 85243

Function(s)

protein binding ATP binding 1-phosphatidylinositol-3-kinase activity phosphatidylinositol 3-kinase activity 1-phosphatidylinositol-4-phosphate 3-kinase activity insulin receptor substrate binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups phosphotransferase activity, alcohol group as acceptor kinase

Process(es)

activation of MAPK activity endothelial cell proliferation regulation of cell-matrix adhesion phosphatidylinositol biosynthetic process cellular calcium ion homeostasis autophagy chemotaxis homophilic cell adhesion via plasma membrane adhesion molecules signal transduction transmembrane receptor protein tyrosine kinase signaling pathway G-protein coupled receptor signaling pathway positive regulation of autophagy positive regulation of gene expression phosphatidylinositol 3-kinase signaling regulation of phosphatidylinositol 3-kinase signaling cell migration platelet activation phosphatidylinositol-3-phosphate biosynthetic process Fc-epsilon receptor signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis embryonic cleavage phosphatidylinositol phosphorylation vascular endothelial growth factor receptor signaling pathway phosphatidylinositol-mediated signaling T cell receptor signaling pathway leukocyte migration angiogenesis involved in wound healing platelet aggregation regulation of clathrin-mediated endocytosis adaptive immune response protein phosphorylation endocytosis inflammatory response cell adhesion response to wounding phosphorylation innate immune response cell chemotaxis

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