Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
PA5-64710
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human Shc3 (Phospho-Tyr424)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2664263
Product Specific Information
Phospho-SHC3 (Tyr424) Polyclonal Antibody detects endogenous levels of SHC3 only when phosphorylated at Tyr424.
Target Information
Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: N-Shc; Neuronal Shc; Protein Rai; SH2 domain protein C3; SHC (Src homology 2 domain containing) transforming protein 3; SHC-transforming protein 3; SHC-transforming protein C; Shc3 p51; src homology 2 domain-containing transforming protein C3; Src homology 2 domain-containing-transforming protein C3
Gene Aliases: N-Shc; NSHC; RAI; SHC3; SHCC
UniProt ID: (Human) Q92529, (Mouse) Q3ZAX2
Entrez Gene ID: (Human) 53358, (Rat) 114858, (Mouse) 20418
MAPK cascade
transmembrane receptor protein tyrosine kinase signaling pathway
epidermal growth factor receptor signaling pathway
Ras protein signal transduction
central nervous system development
learning or memory
synaptic transmission, glutamatergic
positive regulation of GTPase activity
intracellular signal transduction
signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support