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7TM Antibodies
Phospho-Sphingosine 1-Phosphate Receptor 5 (Ser345) Polyclonal Antibody
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Application
FIGURE: 1 / 1
Phospho-Sphingosine 1-Phosphate Receptor 5 (Ser345) Antibody (7TM0279A) in WB
Agonist-induced Serine345 phosphorylation of the Sphingosine 1-Phosphate Receptor 5. Upper panel, HEK293 cells stably expressing the S1P5-Receptor (S1P5) were either not exposed or exposed to 1 µM of S1P5-Receptor Agonists S1P for 30 minutes. Cells were lysed and immunoblotted with the anti-pS345-S1P5 antibody (7TM00279A) at a dilution of 1:1,000. Lower panel, blot was stripped and reprobed with an phosphor... View More
Product Details
7TM0279A
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic phosphopeptide derived from human S1P5 around the phosphorylation site of Ser345.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
Dulbecco's PBS, pH 7.4
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1) are S1P receptors; others (e.g., EDG2) are LPA receptors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Endothelial differentiation G-protein-coupled receptor 8; endothelial differentiation, sphingolipid G-protein-coupled receptor, 8; S1P receptor 5; S1P receptor Edg-8; S1P(5) receptor; Sphingosine 1-phosphate receptor 5; Sphingosine 1-phosphate receptor Edg-8; sphingosine 1-phosphate receptor EDG8
Gene Aliases: Edg-8; EDG8; S1P5; S1PR5; SPPR-1; SPPR-2
UniProt ID: (Human) Q9H228
Entrez Gene ID: (Human) 53637
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