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Invitrogen
Phospho-Synapsin 1 (Ser9) Polyclonal Antibody
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Application
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Phospho-Synapsin 1 (Ser9) Antibody (PA5-104822) in IHC (P)
Immunohistochemistry analysis of Phospho-Synapsin 1 (Ser9) in mouse brain tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with Phospho-Synapsin 1 (Ser9) polyclonal antibody (Product # PA5-104822) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-104822
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SYN1(Accession P17600), corresponding to amino acid residues around phosphorylated Ser9.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2816295
Product Specific Information
Antibody detects endogenous levels of Synapsin I only when phosphorylated at Serine 9.
Target Information
SYN1 (synapsin 1) is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins that associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains and are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. Synapsin 1 plays a role in regulation of axonogenesis and synaptogenesis. It serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Brain protein 4.1; synapsin 1; Synapsin I; Synapsin-1; truncated synapsin 1-S
Gene Aliases: Syn-1; SYN1; Syn1-S; SYN1a; SYN1b; SYNI
UniProt ID: (Human) P17600, (Rat) P09951, (Mouse) O88935
Entrez Gene ID: (Human) 6853, (Rat) 24949, (Mouse) 20964
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