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Invitrogen
Phospho-Trf2 (Thr188) Polyclonal Antibody
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Application
FIGURE: 1 / 4
Phospho-Trf2 (Thr188) Antibody (PA5-105937) in ICC/IF
Immunofluorescent analysis of Phospho-Trf2 (Thr188) in HeLa cells(4h of LPS treatment). Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and Phospho-Trf2 (Thr188) polyclonal antibody (Product # PA5-105937) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 ... View More
Product Details
PA5-105937
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TERF2(Accession Q15554), corresponding to amino acid residues around phosphorylated Thr188.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2817336
Product Specific Information
Antibody detects endogenous levels of TRF2 only when phosphorylated at Thr188.
Target Information
TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Telomeric DNA-binding protein; telomeric repeat binding protein 2; Telomeric repeat-binding factor 2; TTAGGG repeat-binding factor 2
Gene Aliases: TERF2; TRBF2; TRF2
UniProt ID: (Human) Q15554, (Mouse) O35144
Entrez Gene ID: (Human) 7014, (Rat) 361403, (Mouse) 21750
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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