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Invitrogen
Phospho-cGKII (Ser126) Polyclonal Antibody
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Application
FIGURE: 1 / 4
Phospho-cGKII (Ser126) Antibody (PA5-105913) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded Phospho-cGKII (Ser126) in human pancreas tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with Phospho-cGKII (Ser126) polyclonal antibody (Product # PA5-105913) using a dilution of 1:200 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
Product Details
PA5-105913
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PRKG2(Accession Q13237), corresponding to amino acid residues around phosphorylated Ser126.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2817312
Product Specific Information
Antibody detects endogenous levels of CGK2 only when phosphorylated at Ser126.
Target Information
PRKG2 (PKG2, cGKII) exhibits many cellular functions and has cAMP- and cGMP-dependent protein kinase activity. cGKII is thought to play a key role in a diverse set of physiological pathway. cGKII may mediate intestinal secretion of water and electrolytes induced by the E. coli toxin STa and the intestinal peptide guanylin. Identification of the pathway that mediates intestinal fluid secretion by E. coli. cGKII is postulated to be a molecular switch that couples the cessation of proliferation and the start of hypertrophic chondrocyte differentiation through attenuating SOX9 function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CGK 2; cGK2; cGKII; cGMP dependent protein kinase type II; cGMP-dependent protein kinase 2; cGMP-dependent protein kinase II; EC 2.7.11.12; protein kinase cGMP- dependent type 2; protein kinase, cGMP- dependent, type 2; protein kinase, cGMP- dependent, type II; testicular tissue protein Li 99; type II cGMP-dependent protein kinase
Gene Aliases: AW212535; cGK-II; cGK2; CGKII; GDPKII; PRKG2; PRKGR2
UniProt ID: (Human) Q13237, (Rat) Q64595
Entrez Gene ID: (Human) 5593, (Rat) 25523, (Mouse) 19092
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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