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7TM Antibodies
Phospho-kappa-Opioid Receptor (Ser356, Thr357) Polyclonal Antibody
Application
FIGURE: 1 / 2
Phospho-kappa-Opioid Receptor (Ser356, Thr357) Antibody (7TM0318A) in WB
Agonist-induced Serine356/Threonine357 phosphorylation of the kappa-Opioid Receptor. Upper panel, HEK293 cells stably expressing the kappa-Opioid Receptor (KOP) were either not exposed or exposed to 10 µM of selective kappa-opioid receptor Agonist U50, 488Hfor 30 minutes. Cells were lysed and immunoblotted with the anti-pS356/pT357-KOP antibody (7TM0318A) at a dilution of 1:1,000. Lower panel, blot was stri... View More
Product Details
7TM0318A
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic phosphopeptide derived from human KOP around the phosphorylation site of Ser356/Thr357.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
Dulbecco's PBS, pH 7.4
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: K-OR-1; kappa opioid receptor; Kappa-type opioid receptor; KOPR1; KOR-1; MSL-1; Opiate receptor, kappa-1; opioid receptor, kappa 1; opioid receptor, kappa 2; Ork1
Gene Aliases: K-OR-1; KOR; KOR-1; MSL-1; OPRK; OPRK1; Oprk2; R21; Ror-d
UniProt ID: (Human) P41145, (Mouse) P33534, (Rat) P34975
Entrez Gene ID: (Human) 4986, (Mouse) 18387, (Rat) 29335
immune response
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
chemical synaptic transmission
sensory perception
behavior
locomotory behavior
response to radiation
sensory perception of pain
adenylate cyclase-inhibiting opioid receptor signaling pathway
response to insulin
positive regulation of dopamine secretion
negative regulation of luteinizing hormone secretion
opioid receptor signaling pathway
positive regulation of locomotion
maternal behavior
eating behavior
response to morphine
response to estrogen
estrous cycle
response to ethanol
regulation of saliva secretion
behavioral response to cocaine
sensory perception of temperature stimulus
defense response to virus
regulation of sensory perception of pain
cellular response to lipopolysaccharide
positive regulation of p38MAPK cascade
positive regulation of potassium ion transmembrane transport
regulation of aerobic respiration
response to acrylamide
conditioned place preference
regulation of energy homeostasis
signal transduction
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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