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Progen

Plakoglobin Monoclonal Antibody (PG 5.1)

View all (48) gamma Catenin antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (5)

Application

Plakoglobin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 5

Plakoglobin Antibody (690005S) in IHC (P)

IHC of human oral mucosa (courtesy of J.Hess, University Hospital Heidelberg).

Plakoglobin Antibody in Western Blot (WB)

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Product Details

690005S

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

1:25-1:100

Immunocytochemistry (ICC/IF)

10 µg/mL

Product Specifications

Species Reactivity

Bovine, Dog, Human, Mouse, Rat, Zebrafish

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

PG 5.1

Immunogen

Plakoglobin, "band 5" protein from bovine snout epidermis

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 0.5% BSA

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

JUP is a major cytoplasmic protein which is the only known constituent common to sub membranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: catenin (cadherin-associated protein), gamma 80kDa; Catenin gamma; Desmoplakin III; Desmoplakin-3; gama-catenin; Gamma-catenin; gamma-catenin (plakoglobin); Junction plakoglobin; Junction plakoglobin a; OTTHUMP00000164735; Plakoglobin; Plakoglobin-1a

Gene Aliases: ARVD12; cb80; CTNNG; D930025P04Rik; danPG; DP3; DPIII; fb11b06; JUP; jupa; PDGB; PG; PKGB; wu:fb11b06

UniProt ID: (Bovine) Q8SPJ1, (Human) P14923, (Rat) Q6P0K8, (Mouse) Q02257, (Zebrafish) Q9PVF7

Entrez Gene ID: (Bovine) 445543, (Dog) 480522, (Human) 3728, (Rat) 81679, (Mouse) 16480, (Zebrafish) 30415

Function(s)

structural molecule activity protein binding protein homodimerization activity transcription coactivator activity signal transducer activity structural constituent of cell wall protein kinase binding protein phosphatase binding alpha-catenin binding cadherin binding cell adhesion molecule binding cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication cadherin binding involved in cell-cell adhesion nuclear hormone receptor binding

Process(es)

positive regulation of cell-matrix adhesion desmosome assembly cell migration regulation of cell proliferation positive regulation of protein import into nucleus negative regulation of blood vessel endothelial cell migration skin development positive regulation of angiogenesis detection of mechanical stimulus positive regulation of sequence-specific DNA binding transcription factor activity endothelial cell-cell adhesion cellular response to indole-3-methanol protein localization to plasma membrane bundle of His cell-Purkinje myocyte adhesion involved in cell communication regulation of heart rate by cardiac conduction regulation of ventricular cardiac muscle cell action potential atrioventricular valve morphogenesis negative regulation of Wnt signaling pathway involved in heart development cell adhesion heart development negative regulation of Wnt signaling pathway positive regulation of transcription from RNA polymerase II promoter cytoskeletal anchoring at plasma membrane signal transduction single organismal cell-cell adhesion adherens junction organization adherens junction assembly protein heterooligomerization establishment of protein localization to plasma membrane positive regulation of canonical Wnt signaling pathway regulation of cell fate specification ventricular cardiac muscle cell action potential bundle of His cell to Purkinje myocyte communication regulation of nucleic acid-templated transcription

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