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Product Details
BS-24450R-BIOTIN
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Polycystin 2
Conjugate
Biotin
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS with 50% glycerol, 1% BSA
Contains
0.03% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Functions as a calcium permeable cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD1L1 in cilia to facilitate flow detection in left/right patterning.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Autosomal dominant polycystic kidney disease type II protein; PC2; polycystic kidney disease 2 (autosomal dominant); Polycystic kidney disease 2 protein; Polycystin-2; Polycystwin; R48321; Transient receptor potential cation channel subfamily P member 2; transient receptor potential cation channel, subfamily P, member 2
Gene Aliases: APKD2; Pc-2; PC2; PKD2; PKD4; TRPP2
UniProt ID: (Human) Q13563
Entrez Gene ID: (Human) 5311
receptor binding
voltage-gated ion channel activity
voltage-gated calcium channel activity
voltage-gated sodium channel activity
potassium channel activity
calcium ion binding
protein binding
cytoskeletal protein binding
voltage-gated cation channel activity
identical protein binding
protein homodimerization activity
actinin binding
HLH domain binding
ion channel binding
calcium-induced calcium release activity
ATPase binding
phosphoprotein binding
muscle alpha-actinin binding
ion channel
branching involved in ureteric bud morphogenesis
liver development
embryonic placenta development
heart looping
detection of nodal flow
calcium ion transport
cell cycle arrest
JAK-STAT cascade
determination of left/right symmetry
heart development
negative regulation of cell proliferation
spinal cord development
neural tube development
regulation of cAMP metabolic process
positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
cellular response to reactive oxygen species
metanephric part of ureteric bud development
sodium ion transmembrane transport
aorta development
regulation of cell proliferation
cytoplasmic sequestering of transcription factor
positive regulation of nitric oxide biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
detection of mechanical stimulus
release of sequestered calcium ion into cytosol
centrosome duplication
regulation of postsynaptic membrane potential
negative regulation of ryanodine-sensitive calcium-release channel activity
placenta blood vessel development
renal tubule morphogenesis
renal artery morphogenesis
calcium ion transmembrane transport
positive regulation of cell cycle arrest
cellular response to hydrostatic pressure
cellular response to osmotic stress
cellular response to fluid shear stress
potassium ion transmembrane transport
determination of liver left/right asymmetry
metanephric mesenchyme development
mesonephric tubule development
mesonephric duct development
metanephric smooth muscle tissue development
metanephric cortex development
metanephric ascending thin limb development
metanephric cortical collecting duct development
metanephric distal tubule development
metanephric S-shaped body morphogenesis
regulation of calcium ion import
negative regulation of G1/S transition of mitotic cell cycle
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