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Invitrogen
Prothrombin Polyclonal Antibody
Product Details
PA1-43062
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Murine Prothrombin.
Conjugate
Form
Liquid
Concentration
16.3 mg/mL
Purification
SDS-PAGE
Storage buffer
50% water with 50% glycerol
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2101045
Product Specific Information
PA1-43062 detects Prothrombin in mouse samples.
PA1-43062 has successfully been used in Western blot and ELISA applications.
PA1-43062 was derived from mouse prothrombin.
Target Information
Prothrombin or Coagulation factor II, is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: coagulation factor 2; Coagulation factor II; coagulation factor II (thrombin); prepro-coagulation factor II; Prothrombin; prothrombin B-chain; serine protease; thrombin
Gene Aliases: Cf-2; Cf2; F2; FII; PT; RPRGL2; THPH1
UniProt ID: (Mouse) P19221, (Human) P00734
Entrez Gene ID: (Mouse) 14061, (Rat) 29251, (Human) 2147
positive regulation of protein phosphorylation
proteolysis
acute-phase response
cell surface receptor signaling pathway
blood coagulation
positive regulation of cell proliferation
regulation of cell shape
response to wounding
regulation of gene expression
positive regulation of phosphatidylinositol 3-kinase signaling
response to inactivity
platelet activation
positive regulation of blood coagulation
positive regulation of cell growth
positive regulation of collagen biosynthetic process
wound healing
fibrinolysis
negative regulation of proteolysis
negative regulation of astrocyte differentiation
positive regulation of release of sequestered calcium ion into cytosol
regulation of cytosolic calcium ion concentration
cellular response to mechanical stimulus
positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of reactive oxygen species metabolic process
signal peptide processing
ER to Golgi vesicle-mediated transport
multicellular organism development
blood coagulation, intrinsic pathway
negative regulation of platelet activation
peptidyl-glutamic acid carboxylation
regulation of blood coagulation
cellular protein metabolic process
leukocyte migration
negative regulation of fibrinolysis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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