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Prothrombin Antibody (MA5-50985) in IHC (P)
Immunohistochemistry (Paraffin) analysis of Prothrombin in Rat Liver Tissue. Samples were incubated in Prothrombin monoclonal antibody (Product # MA5-50985) using a dilution of 20 µg/mL followed by HRP-Linked Caprine Anti-Mouse IgG at a dilution of 2 µg/mL and DAB staining.
Product Details
MA5-50985
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
C19
Immunogen
Recombinant Rat F2 protein, Ser201-Arg323 (Accession #P18292)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% Proclin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_3091311
Target Information
Prothrombin or Coagulation factor II, is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: coagulation factor 2; prothrombin; thrombin
Entrez Gene ID: (Rat) 29251
positive regulation of protein phosphorylation
proteolysis
acute-phase response
cell surface receptor signaling pathway
blood coagulation
positive regulation of cell proliferation
regulation of cell shape
response to wounding
regulation of gene expression
positive regulation of phosphatidylinositol 3-kinase signaling
response to inactivity
platelet activation
positive regulation of blood coagulation
positive regulation of cell growth
positive regulation of collagen biosynthetic process
wound healing
fibrinolysis
negative regulation of proteolysis
negative regulation of astrocyte differentiation
positive regulation of release of sequestered calcium ion into cytosol
regulation of cytosolic calcium ion concentration
cellular response to mechanical stimulus
positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of reactive oxygen species metabolic process
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