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NeoBiotechnologies
QKI/Protein Quaking Monoclonal Antibody (PCRP-QKI-2F10)
Product Details
9444-MSM1-P0
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2c
Class
Monoclonal
Type
Antibody
Clone
PCRP-QKI-2F10
Immunogen
Recombinant full-length human QKI protein
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4° C, do not freeze
Shipping conditions
Wet ice
Target Information
This gene encodes the sacsin protein, which includes a UbL domain at the N-terminus, a DnaJ domain, and a HEPN domain at the C-terminus. The gene is highly expressed in the central nervous system, also found in skin, skeletal muscles and at low levels in the pancreas. This gene includes a very large exon spanning more than 12.8 kb. Mutations in this gene result in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), a neurodegenerative disorder characterized by early-onset cerebellar ataxia with spasticity and peripheral neuropathy. Sacsin has been found to protect against mutant ataxin-1. A pseudogene associated with this gene is located on chromosome 11. Alternative splicing of this gene results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp586I0923; homolog of mouse quaking QKI (KH domain RNA binding protein); Hqk; KH domain-containing RNA-binding protein QKI; Protein quaking; QKI, KH domain containing, RNA binding; quaking homolog, KH domain RNA binding; RNA Binding (QKI); RNA binding protein HQK
Gene Aliases: HKQ; Hqk; hqkI; QK; QK1; QK3; QKI
UniProt ID: (Human) Q96PU8
Entrez Gene ID: (Human) 9444
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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